BACKGROUND Propensity to colonic neoplasia differs between the right and left colon. AIMS To examine whether this difference may be related to regional differences in epithelial apoptosis, in expression of a proapoptotic regulatory protein, Bak, and in proliferation. PATIENTS Individuals with no history of colorectal neoplasia. METHODS Archival blocks of colorectal tissues were immunostai...

BACKGROUND There is a difference in the location of colorectal mucosal lesions and invasive cancers. AIMS To ascertain whether the location of colorectal neoplasms reflects the carcinogenesis pathway. METHODS The subject material consisted of 4147 neoplastic lesions that had been resected endoscopically or surgically from 5025 patients. Mucosal lesions and submucosal cancers were classified...

Delay in diagnosis and treatment can result in serious complications in the otherwise benign neonatal small left colon syndrome. This condition was first distinguished from other forms of microcolon by Davis et al. (1974), and subsequently reports have suggested a surgical orientation. The condition presents as a low obstruction of the large bowel, similar to Hirschsprung's disease in the newbo...

H emangiomas are uncommon in the gastrointestinal tract, but cavernous hemangiomas are the most common type encountered. Colonic cavernous hemangiomas most often involve the rectum and, when symp tom atic, often present with evidence of gastrointestinal bleeding. Abdom in al solid organ involvement may be an incidental finding on radiologic investigations. Rarely, hemangiomas of the colon may f...

A man with metastatic carcinoma of the colon had a bone scan which revealed urinary retention in the left kidney. Ten months later, a Tc-99m-DTPA renai glomerular study showed the left kidney to have only 8% of total renal function. Fifteen months after that, (he same kidney demonstrated 9% of total function, while the right kidney had evolving obstruction due to his neoplasm. The case sh...

OBJECTIVE Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS). METHODS...

AV In the analysis of the Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial that we presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO), we defined right-sided colon cancer as cancer of the cecum and the ascending colon up to the hepatic flexure. Left-sided colon cancer comprises cancer of the splenic flexure and cancer in regions distal to the splenic fl...

Background: The equine colic, which is caused by the presence of enteroliths that are most often found in the small or large colon, is typical for certain geographical regions (dry and hot climate). A diet rich in alfalfa is one of the highest risk factors. The earliest symptoms include weight loss and repeated episodes of colic pain. Aims: To present the resul...