despite the availability of various alkaline phosphatase (alp) isoenzymes, the calf enzyme is being used in current enzyme assays as the detector enzyme. the glycosylation pattern of this enzyme makes it a suitable ligand for binding to wheat germ agglutinin lectin (wga). as a result of this property, the enzyme can not be used as a conjugate with this lectin, and the calf enzyme conjugates can...

Abstract Siglec-8, a lectin involved in the suppression of allergic responses, is considered therapeutic target for developing glycan materials that enable regulation inflammatory diseases. In such materials, “multivalent effect” essential regulating immune responses. The dramatically increases apparent affinities (avidities) glycan-lectin interactions by clustering ligand multivalently. Numero...

This article reviews lectins of animal and plant origin that induce apoptosis and autophagy of cancer cells and hence possess the potential of being developed into anticancer drugs. Apoptosis-inducing lectins encompass galectins, C-type lectins, annexins, Haliotis discus discus lectin, Polygonatum odoratum lectin, mistletoe lectin, and concanavalin A, fucose-binding Dicentrarchus labrax lectin,...

mannose-binding lectin (mbl) is a protein of innate immune system that is involved in opsonization and complement activation. mbl deficiency is associated with predisposition to infectious diseases; however subnormal levels are also seen in healthy subjects. the aim of this study was to investigate the prevalence and clinical manifestation of mbl deficiency in patients with increased susceptibi...

there is growing evidence that lectin-carbohydrate interactions can mediate the infection of parasites to their insect vector. many insect species are host or vectors of protozoan or metazoan parasites that cause socially and economically important disease such as malaria and leishmaniasis. however, relatively little work has been undertaken concerning the interaction of insect immunity against...

Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrian...

The involvement of endocannabinoid receptors in the antinociceptive activity Lonchocarpus araripensis lectin (LAL) was investigated model carragenan-induced hypernociception. Swiss mice received LAL (10 mg/kg) by intravenous (i.v.) route 30 min before subcutaneous (s.c.) injection carrageenan paws. Animals were treated with antagonists CB1 (AM251) or CB2 (AM630) cannabinoid lectin. inhibited hy...

background: although cockroaches are mechanical vector of many pathogens, still biological transmission of pathogens via these insects is controversial. more covenant immune defense in the hemolymph of cockroaches may take this ad­vantage to block any adaptation of pathogens regarding to biological transmission. lectin molecules in hemolymph of in­sects play as mediators of nonself recognition,...

Background: The ethno-medical significance of Clerodendrum genus raises the interest towards the characterization of its seed lectin by inexpensive and most effective technique.Objective: The focus of this study is the purification, characterization, and evaluation of the antioxidant and antiproliferative potential of a galactose-specific lectin from Cler...