Chromium compounds are potent toxic and carcinogenic substances. With respect to toxicity, hepatic and renal toxicity have been reported both in workers and in animals exposed to chromium (VI). Chromium (VI) compounds induces DNA damage in vivo and in cultured cells as well as the cytotoxicity evaluated by the leakage of lactate dehydrogenase. The present study reports the cytotoxicity of chrom...

Chitosan, a naturally derived polymer, has been shown to possess antimicrobial and anti-inflammatory properties; however, little is known about the effect of chitosan on the immune responses and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) activities in normal mice. The aim of the present study was to investigate whether chitosan h...

Background: Persistently infected cells by herpesvirus (HSV, CMV, EBV) and their dysfunction are associated with different disorders. The immune and endocrine systems are involved in pathogenesis of herpesvirus infection. Changes of IFN-γ, IL-4, DHEAS and cortisol level are a part of the regulatory mechanisms of the immune and endocrine system responses in persistent herpesvirus infection. Obje...

Abbreviations used: ALT, Alanine aminotransferase; ApoB, Apolipoprotein B; AST, Aspartate aminotransferase; ER, Endoplasmic Reticulum; GPT, Glutamic Pyruvic Transaminase; GOT, Glutamic Oxaloacetic Transaminase; GSH, Reduced glutathione; HDL, High density lipoprotein; HMGR, HMG-CoA reductase; LDH, lactate dehydrogenase; Lo, Lovastatin; MTP, Microsomal triglycerides transfer protein; MTPi, MTP in...

We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis in man, have been extensively studied in animals, but little is known about the uptake and handling by human livers. Human liver tissue was obtained from livers procured from multiorgan donors and ...

Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might play a crucial role in inducing multi-organ injury. Male C57BL/6J mice (n = 6-...

OBJECTIVES Sepsis is a severe inflammatory disorder that may lead to multiple organ failure. Lipopolysaccharide (LPS) is associated with Gram-negative sepsis and can activate monocytes and macrophages to release pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO) and anti-inflammatory mediator such as interleukin-10 (IL-10). In this present study, we us...

BACKGROUND Hemorrhagic shock (HS) followed by resuscitation can induce the production of several inflammatory mediators and lead to multiple organ dysfunction. The molecular mechanism of biologic responses to rosiglitazone has an anti-inflammatory effect. The present study was designed to investigate the effects of rosiglitazone on physiopathology and inflammatory mediators after HS in rats. ...

Abstract Background Brain metastases (BM) are the most frequent neoplasm in central nervous system (CNS) and primary tumors frequently involved melanoma, lung cancer breast cancer. CNS localisation is associated with poor prognosis, stereotactic radiosurgery (SRS) represents a treatment option for patients good performance status. Glutamate (Glu) neurotransmitter which plays facilitating role c...

BACKGROUND: In patients with coronavirus disease-19 (COVID-19), serious biomarkers (liver function tests and renal functions tests) (urea, creatinine, GOT, GPT, LDH) are determined immediate to assess in prognosis of the severity disease. AIM: The aim study was determine correlation between among COVID-19 patients. METHODS: A cross-sectional study, a total 90 who attending Al-Hussein Medical Ci...