Active tuberculosis (TB) in the UK predominantly affects the non-UK born, but is generally not manifest at the time of UK entry. Strategies to detect latent TB infection (LTBI) in this population are, therefore, important. To date, targeted screening has focused on TB risk estimates based on the incidence in the country of origin. Using TB incidence in the UK and migration data, we estimated th...

BACKGROUND Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may allow discrimination between active tuberculosis and latent tuberculosis infection. METHODS A prospective comparison of M. tuberculosis-specific cellular immunity in subjects with active tuberculosis and latent tuberculosi...

Background: Tuberculosis of the genital tract is one of the major causes of gynecological morbidity. Genital TB affects about 12% of patients with pulmonary tuberculosis and represents 15-20% of extrapulmonary tuberculosis. Genital TB may be asymptomatic but involves genital organs such as fallopian tubes, endometrium, ovaries, cervix, vulva/ vagina and myometrium. The major presenting symptom ...

A promising test to distinguish between active tuberculosis and latent tuberculosis As pointed out by the authors of the case report, the distinction between active tuberculosis (TB) and latent tuberculosis is impossible with the blood tests in conventional use. 1 Nevertheless what seems to show great promise is the use of host RNA expression profiles to distinguish between active and latent tu...

Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed during active tuberculosis disease. Elevated mutation rates are presumed risk factors for the development of drug resistance. Therefore, the inves...

Introduction: Limited data are available on the relationship between nutritional status and tuberculosis. The aim of this study was to evaluate and compare the body mass index (BMI) and serum albumin level in patients with active tuberculosis (ATB) and latent tuberculosis (LTB). Materials and Methods: A cross-sectional study was conducted on 17 patients newly diagnosed with pulmonary TB  who we...

background: prompt diagnosis and treatment of latent tuberculosis (tb) infection (ltbi) are needed to control tb. the aim of the study was to compare the performance of quanti feron-tb test (qft) with conventional tst for the diagnosis of ltbi. methods: in this analytical - comparison study, we enrolled 87 nurses working in teaching hospitals in ahvaz. all study subjects were tested by tst.  ts...

results almost 8% of the personnel showed positive tst (over 10 mm) reaction while 29% of them had considerable t - cell reactivity against ppd in elispot assays. however, the esat - 6 reactivity was found only in one case of hcws. no correlation was found between the patterns of the reactions and the age or the duration of the employment or previous vaccination history of the participants. the...