L-asparaginase is an enzyme that catalyzes the conversion of L-asparagine to L-aspartate and ammonia. The important application of the L-asparaginase enzyme is in the treatment of acute lymphoblastic leukemia, Hodgkin disease, acute myelocytic leukemia, chronic lymphocytic leukemia, lymphosarcoma treatment, reticulosarcoma and melanosarcoma. In the present study, the L-asparaginase from Erwinia...

Enzymes are the selective proteins with high specificity that catalyze all the metabolic reactions in living organisms. Millions of enzymes are produced by prokaryotic and eukaryotic organisms. Use of microbial enzymes as drugs is an important research in the field of pharmaceutical industries. One of the most important discovery in this field is an enzyme L-asparaginase discovered by Clementi ...

The physicochemical properties of the antileukemic Lasparaginase from Erwinia carotovora have been studied and compared with those of the corresponding clinically effective enzyme from Escherichia coli B. Although both enzymes are tetramers with similar molecular weight, the amino acid compositions are distinctly different and the Erwinia enzyme is more basic as judged by polyacrylamide electro...

L-asparaginase is one of the known drugs in the treatment of cancer, especially acute lymphoblastic leukemia. In recent years several bio-conjugation protocols have been developed to improve the pharmacokinetic and immunological properties of anti-leukemic enzyme, L-asparaginase. In this study, fifty two bacilli species were newly isolated in our laboratory and screened for their ability to pro...

L-asparaginase (L-asparagine amido hydrolase, E.C.3.5.1.1) is an extra cellular enzyme that has received considerable attention since it is used as an anticancer agent. L-asparaginase belongs to an amidase group that hydrolyses the amide bond in Lasparagine to aspartic acid and ammonia. The clinical action of this enzyme as an anti-carcinogenic is attributed to the reduction of L-asparagine; tu...

2277 Mitochondrial Thymidine-Deoxyuridine-phosphorylating Activity and the Replication of Mitochondrial DNA. Saul Kit and Yoshiichi Minekawa. 2289 Aflatoxin Bi, a Hepatocarcinogen in the Infant Mouse. 5. D. Vesselinovitch, N. Mihailovlch, G. N. Wogan, L. S. Lombard, and K. V. N. Rao. 2292 Detection of Endotoxin in Commercial LAsparaginase Preparations by Complement Fixation and Separation by Ch...

Recently Sams et all and Solano et aI2 claimed a high incidence of disseminated intravascular coagulation (DIC) during the remission induction in adult patients with acute lymphoblastic leukemia (ALL) before any treatment with L-asparaginase. Sams et all found low fibrinogen levels (<160 mg/dL) in 3 1 of 45 patients (68W), with severe hypofibrinogenaemia (< 100 mg/dL) in 14 (3 1%). Venous throm...