BACKGROUND Recent research indicates that CD133 are expressed in several kinds of stem cells, among which, its high expression in laryngeal carcinoma has caused wide concern. To further explore efficaciously targeting drugs to laryngeal carcinoma stem cells (CSCs), we transplanted a solid tumor from CSCs into abdominal subcutaneous tissue of nude mice, and then compared the biological character...

BACKGROUND The aim of this study was to investigate the role of temperature and humidity in positive continuous pressure flow-induced apnea. METHODS Forty-two adult male Sprague-Dawley rats were used in a functionally isolated laryngeal animal model. In study 1, animals were challenged with laryngeal stimulation for 1 minute to detect the possibility of adaptation. In study 2, different airfl...

BACKGROUND Laryngeal cancer is a malignant head and neck tumor with high morbidity and high mortality in humans. Recently, treatments with Chinese medicines and their extracts have gradually received great attention, and studies suggest that Boschniakia rossica polysaccharide (BRP) has potential anti-tumor activity. Therefore, this study investigating the role of BRP in inducing apoptosis in hu...

OBJECTIVE/HYPOTHESIS Age-associated muscular changes and fatigue have been shown to affect phonatory function. Reductions in blood flow with aging could translate to reductions in oxidative capacity within laryngeal muscles and increased fatigability. We tested the hypothesis that there would be increased capillary red blood cell (RBC) velocity and a reduction of capillary density in the thyroa...

Canine brachycephalic airway syndrome is a progressive disease that affects many brachycephalic dogs. This article describes the components of this syndrome and focuses on acute emergency management and long-term conservative management of these patients. Surgical management is described in a companion article. Canine Brachycephalic Airway Syndrome: Pathophysiology, Diagnosis, and Nonsurgical M...

AIM AND OBJECTIVE Laryngeal carcinoma is one of the most aggressive cancers of the head and neck region. The survival rate of patients with laryngeal carcinoma is low due to its late metastases and resistance to chemotherapy and radiotherapy. It was reported that mTOR was involved in the growth and apoptosis of various cancer cells. The aim of this study was to detect the effects of mTOR inhibi...

Hosnieh Farahani, Mehrdad. "Modeling of the human larynx with application to the influence of false vocal folds on the glottal flow. ii To my parents iii ACKNOWLEDGMENTS I would like to thank my adviser Dr. Sarah Vigmostad for introducing me to this interesting research project. I am also grateful for her guidance and support. In addition, I am thankful to my committee members for their suggest...

Multiple imaging modalities are used to obtain qualitative and quantitative data on laryngeal height and state during pharyngeal consonant production. Videofluoroscopy provides insight into the relative changes in pharyngeal and epilaryngeal lumina, allowing us to compare the roles these structures play in epilaryngeal constriction. Simultaneous laryngoscopy and laryngeal ultrasound allow us to...