Migration from blood to tissue modulates eosinophil function, possibly through interactions with endothelial cells. The effects of contact with and migration through endothelial cells on eosinophil expression of surface markers and release of leukotriene C4 were evaluated. A small proportion (2.6%) of eosinophils spontaneously migrated through endothelial cell monolayers. Activation of endothel...

Intravitreal infection of guinea pigs with second-stage larvae of Toxocara canis and second- and fourth-stage larvae of Ascaris suum induced intraocular IgE antibodies and a dense eosinophil infiltration in the anterior chamber and throughout the uveal tract. The eosinophil infiltrate began within 1 day after infection and persisted for as long as 51 days. By day 12 after intravitreal infection...

Cuterebriasis in small animals is caused by infestation by, and internal migration of, a larva of the Cuterebra fly. This article presents a case of nasal cuterebriasis in a puppy seen at the Louisiana Veterinary Referral Center and reviews the clinical signs and diagnosis of, and treatment options for, Cuterebra infestations. It also describes an unusual treatment plan to successfully remove t...

Allergic asthma is characterized by eosinophil migration in the airways, which is strictly dependent on the expression of adhesion molecules. This study investigated whether the expression of adhesion molecules on eosinophils is increased and associated with disease activity in allergic asthma. Twenty atopic asthmatic (AA) subjects and nine controls were studied and the expression of lymphocyte...

In general, inflammatory cells cross basement membranes by producing proteinases. To investigate the role of proteinases in eosinophil basement membrane migration, we studied peripheral blood eosinophils in Matrigel-coated chemotaxis chambers. Electron microscopy showed degradation of the Matrigel layer when eosinophils, added to the upper chamber, transmigrated the membrane in the presence of ...

Hookworm-related Cutaneous Larva Migrans (HrCLM) is a pruritic serpiginous cutaneous eruption caused by animal hookworms commonly found in tropical and subtropical areas, especially the Southeastern United States. We describe here a very exceptional HrCLM case showing multiple larva entries/lesions in a 63-yearold white male living in Miami. Clinically he presented with multiple pruritic erythe...

BACKGROUND Accumulation of activated eosinophils in tissue is a hallmark of allergic inflammation. The endocannabinoid 2-arachidonoylglycerol (2-AG) has been proposed to elicit eosinophil migration in a CB2 receptor/Gi/o -dependent manner. However, it has been claimed recently that this process may also involve other mechanisms such as cytokine priming and the metabolism of 2-AG into eicosanoid...

Larva migrans denotes the prolonged migration of a larval parasite in the skin or intestinal organs of an abnormal host, usually man.' There are two types of larva migrans. Visceral larva migrans is the more common type mostly caused by larvae of dog and cat ascarids of the genus Toxocara? A few cases of Cutaneous larva migrans have been reported from Malaysia'' and Singapore,4,S though it has ...