Large Ca transients cause massive endocytosis (MEND) in BHK fibroblasts by nonclassical mechanisms. We present evidence that MEND depends on mitochondrial permeability transition pore (PTP) openings, followed by coenzyme A (CoA) release, acyl CoA synthesis, and membrane protein palmitoylation. MEND is blocked by inhibiting mitochondrial Ca uptake or PTP openings, depleting fatty acids, blocking...

The cuticular parts of the aphid plate organ consist of an outer and an inner layer. Both are transparent and in the space between them are many fine branches of the half dozen, or more, sensory neurones which lie below the plate. Each dendrite narrows, a short distance above its cell body, and assumes the structure of a cilium with 9 pairs of peripheral fibrils, a ciliary collar, and basal bod...

Castellated beams are generally provided with hexagonal and circular openings in the web portion. However, in view of structural applications, appropriate size and shape of openings in web are always a major issue of concern. Research work carried out in optimizing sizes of castellated beam with hexagonal openings have reported that castellated beams fail mainly by local failure modes and stres...

Infilled walls are the major non-structural elements which have significant effects on the seismic behavior of structures. The shape and strength of the brick elements are the main parameters affect the strength of the walls. In addition existence of openings may have a reduction effect. To increase the strength of the wall and to improve its behavior, the borders of the openings may be strengt...

This article examines the proliferation of gambling in United States counties during the 1990s and examines the factors that influence a region’s decision to allow or prohibit casino gambling. Native American casino openings are driven by somewhat different factors than non-Native American casino openings. Both types of casinos are more likely to open in counties with large populations. More im...

steel shear walls, like bracings are a resistance system against wind and earthquake loads, which have more advantages than other systems. this paper is investigating the influence of openings on steel shear walls under increasing static loads. for this purpose, the experiments of other researchers on finite elements method have been checked and after investigating the correctness and precision...

Late openings of sodium channels were observed in outside-out patch recordings from hippocampal neurons in culture. In previous studies of such neurons, a persistent sodium current appeared to underlie the ictal epileptiform activity. All the channel currents were blocked by tetrodotoxin. In addition to the transient openings of sodium channels making up the peak sodium current, there were two ...