Proper completion of mitosis requires the concerted effort of multiple RhoGEFs. Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the intercellular membrane is cleaved between daughter cells. LARG colocalizes with α-tubulin at the spindle poles before localizing to the central spindle. During cyt...

The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two groups. The operating time of LARG was lon...

impact of supply chain drivers on supply chain performance has no far been studied. in this research we want identifying supply chain drivers, classifying them and examining their relationship with iran's supply chain performance. this research has innovation in identifying and classifying drivers and examining relationship between drivers and supply chain performance we used bsc for assessing ...

the aim of this study was to represent effective componentsin demand chain which help organizations attain high performance levelsthrough identification of these components and determining theirdegree of importance. the following questions were major ideas of thisstudy: what are the most effective components in demand chain? andhow are they effective on organizational performance? to this end,m...

the revenue management concept and techniques are applied to model the coordination of supply chain elements. the fundamental premise of this approach is synchronization of a group of business entities consist-ing of a manufacturer and multiple suppliers to achieve an optimal supply chain capacity plans. the output of the supply chain can be various products and thus it is measured in terms of ...

in recent years, there has been a great concern about strategic supply chain management. the supply chain configuration approach is related to strategic management of material and information flows. most of suggested configurations in the part of strategic direction are based on environmental factors and structure-conduct-performance approach. exploring supply chain configuration with emphasis ...

Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho GTPase in cells. Recently, we identified p115RhoGEF, one of the guanine nucleotide exchange factors (GEFs) for Rho, as a direct link between Galpha13 and Rho [Kozasa, T., et al. (1998) Science 280, 2109-2111; Hart, M. J., et al. (1998) Science 280, 2112-2114]. Activated ...

modern manufacturing enterprises are required to collaborate by their business partners through their business process operations such as design, manufacture, distribution, and aftersales services. and furthermore performance evaluation is of great importance for effective supply chain man agement. therefore, dea can help companies to remove some of the in efficiencies in operational processes ...

The rgsRhoGEFs comprise a subfamily of three guanine nucleotide exchange factors, which function in linking heterotrimeric G-proteins to the monomeric RhoGTPase. Here, we reveal the novel finding that oligomerization of leukemia-associated RhoGEF (LARG) functions to prevent nucleocytoplasmic shuttling and to retain LARG in the cytoplasm. We establish that oligomerization is mediated by a predic...

today’s competition is promoted from firm against firm to supply chain versus supply chain, globalization and competition is a common phenomenon so each organization should make its supply chain as a weapon against the others, in doing so this paper presented a conceptual, graphical, step by step methodology to construct supply chain strategies by integrating strategic management’s theories, ap...