A 10-day-old male neonate was admitted with bilious vomiting and gross hematochezia. Peripheral eosinophilia, delayed positive skin prick test to artificial milk, and elevated eosinophil cationic protein levels suggested cow's milk allergy. Fluid infusion with prohibition of oral intake improved the digestive symptoms. Breast-feeding was resumed on hospital day 3 and only casein hydrolysate for...

The increase of food allergy in infants is one of the most severe problems for immediate solution in the developed countries. AIthough breast milk is considered to be the most appropriate food for infants nutritionally, immunologically, physiologically, and mentally, there are some reports that unfortunately suggest allergic sensitization via breast milk. Infants who had not taken any baby food...

hours of cow’s milk ingestion, skin prick tests $3 mm, and serum specific IgE levels $0.35 kU/L for whole cow’s milk, casein, a-lactalbumin, or b-lactoglobulin. Persistence of CMP allergy in the 4 weeks before tolerance induction was based on positive skin and serum testing and a positive double-blind placebo-controlled food challenge to cow’s milk. Exclusion criteria included anaphylactic shoc...

Background Previous animal studies showed that partial whey hydrolyates could prevent acute allergic symptoms in a mouse model for cow’s milk allergy. This effect was even more pronounced in combination with a diet containing a specific non-digestible oligosaccharide mixture of scGalacto(scGOS), lc-Fructo(lcFOS) and Acidic(pAOS) oligosaccharides (in a 9:1:2 ratio). We hypothesized that these hy...

BackgroundBeta-lactoglobulin (BLG) is a bovine lipocalin in milk with an innate defense function. The circumstances under which BLG associated tolerance of or allergy to are not understood.ObjectiveOur aims were assess the capacity ligand-free apoBLG versus loaded (holoBLG) protect mice against by using iron-quercetin complex as exemplary ligand and study molecular mechanisms this protection.Me...

Abstract The rising prevalence of food allergy is strongly correlated with dysbiosis the gut microbiome. Rescuing this by reintroducing specific bacteria a promising method to prevent or treat allergy. We have shown that monocolonization Anaerostipes caccae, species representative healthy infant microbiota, protects against an allergic response milk protein b-lactoglobulin (BLG). Recently we de...

BACKGROUND Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intest...

Summary A novel and recently launched food for special medical purposes was discussed by a multidisciplinary expert panel as an option allergic patients. The newly developed lozenge contains the whey protein beta-lactoglobulin (BLG) well micronutrients iron, zinc vitamin A. BLG loaded with ligands (holo-BLG) is one factor of allergy-protective farm effect in numerous scientific studies. Further...