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The expression of the nuclear protein p53 in oligodendrogliomas was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7) on formalin-fixed, paraffin-embedded material in 84 histologically verified cases, and compared with the histopathological grade and survival. p53-immunoreactive cells were found in 75 per cent of the samples acquired at the first biopsy. The p53 ...

BACKGROUND P53 expression and increased MIB-1 proliferation index have been shown to correlate with invasive behavior in pituitary adenomas. The purpose of this study was to determine whether these indices could be used to predict a higher likelihood of recurrence in clinically nonfunctional pituitary adenomas and thus guide adjuvant therapy. METHODS Fifty-one clinically nonfunctional pituita...

editorial Is the Ki-67 labelling index ready for clinical use? Cancer is one of the leading causes of death worldwide. Identification of biomarkers that can detect cancer early, monitor disease progression or serve as a surrogate marker for prognosis and prediction will enable us to personalise medicine and improve care of cancer patients. Up to now, the leading parameters that define treatment...

We introduce a complexity measure of modal properties of finite structures which generalises the automaticity of languages. It is based on graph-automata like devices called labelling systems. We define a measure of the size of a structure that we call rank, and show that any modal property of structures can be approximated up to any fixed rank n by a labelling system. The function that takes n...

The enzymatic activity of matrix metalloproteinase-9 (MMP-9) suggests that its presence in hypopharyngeal and laryngeal squamous cell carcinomas (HSCCs, LSCCs) could have prognostic value. We tested this hypothesis by quantitative morphometric analysis of immunohistochemical staining in histological sections of 73 stage IV HSCCs and 45 LSCCs (30 cases of stage I/II, 15 cases of stage IV). As co...

Purpose: The PAP smear has significantly reduce the mortality and morbidity of cancer cervix however there is some debates of it as interobserver variability and high false negative and false-positive rates so parameters of cell proliferation have emergedas important diagnostic and prognostic tools. Aim of the Work: This present study aimedtoevaluate the efficiency of Ki67 in differentiating dy...

A review is presented of recently developed methods for quantifying electron microscopical thin sections on which colloidal gold-labelled markers are used to identify and localize interesting molecules. These efficient methods rely on sound principles of random sampling, event counting, and statistical evaluation. Distributions of immunogold particles across cellular compartments can be compare...