Objective(s):One of the major challenges in the field of vaccine design is choosing immunogenic antigens which can induce a proper immune response against complex targets like malignant cells or recondite diseases caused by protozoan parasites such as leishmaniasis. The aim of this study was to find a way to construct artificial liposome-based cells containing fragments of target’s cell membran...

objective(s):one of the major challenges in the field of vaccine design is choosing immunogenic antigens which can induce a proper immune response against complex targets like malignant cells or recondite diseases caused by protozoan parasites such as leishmaniasis. the aim of this study was to find a way to construct artificial liposome-based cells containing fragments of target’s cell membran...

(123)I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane ((123)I-FP-CIT) was approved for clinical use in 2011 by the Food and Drug Administration. (123)I-FP-CIT is a radioligand for brain dopamine transporter (DAT) imaging that is useful for the differential diagnosis of Parkinson disease (PD) and other diseases that mimic PD. The sensitivity and specificity of (123)I-FP-C...

introduction: trastuzumab is a monoclonal antibody that is used in treating breast cancer. we labeled this monoclonal antibody with technetium-99m and performed in vitro and in vivo quality control tests as a first step in the production of a new radiopharmaceutical. methods: trastuzumab was labeled with technetium-99m using succinimidyl hydrazinonicotinamide (hynic) as chelator. radiochemical ...

introduction: nigrothalamocortical tract is one of the important outputs of the basal ganglia, but its role in motor disturbances is still vauge, beacause there is little informations on its connection structure. some electrophysiological and pharmacological studies report that non-dopaminergic outputs originate from reticular part of substatia nigra to thalamus. in this study the topographical...

viral infections are the cause of great economic losses in the poultry industry. development of appropriate reagents and serological diagnostic kits will help to control these infections. the aim of this study is to prepare a peroxidase labeled anti-chicken igg using a mab (5b8) against chicken igg, for detection of chicken antibodies in elisa. hybridoma cells producing the mab 5b8 were culture...

Background Cleft palate (CP) is a common congenital defect. It makes serious difficulties for cleft-affected children. The gold standard of care is autogenous bone grafting which may cause additional problems in donor site along with disappointing results. Tissue engineering is a promising solution for a widespread range of defects and disorders. It is reasonable to utilize this novel technolo...