نتایج جستجو برای: l929 cell

تعداد نتایج: 1684380  

2015
Manman Gu Jing Xu Chunyang Han Youxi Kang Tengfei Liu Yanfei He Yanfei Huang Cuiyan Liu

Berberine, an isoquinoline alkaloid isolated from several traditional Chinese herbal medicines (TCM), exhibits a strong antimicrobial activity in the treatment of diarrhea. However, it causes human as well as animal toxicity from heavy dosage. The present study was conducted to investigate the cytotoxicity of berberine and its possible trigger mechanisms resulting in cell cycle arrest, DNA dama...

2014
Ting Wu Yuanyue Li Deli Huang Felicia Han Ying-Ying Zhang Duan-Wu Zhang Jiahuai Han

Autophagy has diverse biological functions and is involved in many biological processes. The L929 cell death induced by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethyl ketone (zVAD) was shown to be an autophagy-mediated death for which RIP1 and RIP3 were both required. It was also reported that zVAD can induce a small amount of TNF production, which was shown to be re...

Journal: :Journal of cell science 2004
Jinquan Li Qinxi Li Changchuan Xie Huamin Zhou Yuqian Wang Na Zhang Hanjuan Shao Siu Chiu Chan Xuanxian Peng Sheng-Cai Lin Jiahuai Han

Tumor necrosis factor (TNF)-alpha induces caspase-independent cell death in the fibrosarcoma cell line L929. This cell death has a necrotic phenotype and is dependent on production of reactive oxygen species (ROS) in the mitochondria. To identify genes involved in this TNF-induced, ROS-dependent cell death pathway, we utilized retrovirus insertion-mediated random mutagenesis to generate TNF-res...

2014
Mosa-Al-Reza Hadjzadeh Habib Ghanbari Zakieh Keshavarzi Jalil Tavakol-Afshari

BACKGROUND Although the incidence of gastric cancer is declining during the last half century, this cancer still is the second morbid cancer in the world after lung cancer. The incidence of gastric cancer is 26 per 100,000 in Iran. This study evaluated the effect of Alpinia galangal on AGS cells (human gastric adenocarcinoma epithelial cell line) and L929 cells (as a standard cell line originat...

ژورنال: دانشور پزشکی 2011
حامدی, رویا , شاهون, حسین , مجد الحسینی, وحید , ولایی, ناصر , یادگاری, زهرا ,

Background and Objective: Hydroxyapatite (Ca10(PO4 )6(OH)2)  is an important biomaterial in medical and dental applications. Due to low solubility of its particles, it has had little application in bone reformation. For this reason, nanohydroxyapatite (Nano-HA) with a higher surface area and higher solubility has attracted the attention of researchers as an effective strategy for bone grafting ...

2013
Xiaorun Liu Meng Tang Ting Zhang Yuanyuan Hu Shanshan Zhang Lu Kong Yuying Xue

With the widespread use of quantum dots (QDs), the likelihood of exposure to quantum dots has increased substantially. The application of quantum dots in numerous biomedical areas requires detailed studies on their toxicity. In this study, we aimed to determine the threshold dose which reduced or eliminated CdTe-induced toxicity in L929 cells by controlling the exposure dose. We established a c...

Journal: :Journal of virology 1996
J Zoll J M Galama F J van Kuppeveld W J Melchers

The presence of a leader peptide in picornaviruses is restricted to the Cardiovirus and Aphthovirus genera. However, the leader peptides of these two genera are structurally and functionally unrelated. The aphthovirus leader is a protease involved in viral polyprotein processing and host cell translation shutoff. The function of the cardiovirus leader peptide is still unknown. To gain an insigh...

2016
Hirofumi Sawai

It has been shown that necroptosis-caspase-independent programmed necrotic cell death-can be induced by treatment with tumor necrosis factor (TNF) in the L929 murine fibrosarcoma cell line, even in the absence of a caspase inhibitor. Although it was reported that necrostatin-1-a specific inhibitor of necroptosis-inhibited TNF-induced necroptosis in L929 cells, it has not been elucidated whether...

Journal: :The Journal of Experimental Medicine 1983
J Turco H H Winkler

The effect of lymphokine treatment of mouse and human fibroblast cell lines on the growth of Rickettsia prowazekii within the fibroblasts was studied. Treatment of mouse L929 cells with concanavalin A- or antigen-induced mouse lymphokines both before and after infection with R. prowazekii led to clearance of the rickettsiae from a substantial proportion of the cells and suppression of rickettsi...

Journal: :Nano letters 2009
Zhou Li Jinhui Song Giulia Mantini Ming-Yen Lu Hao Fang Christian Falconi Lih-Juann Chen Zhong Lin Wang

The physical behaviors of stationary cells, such as the morphology, motility, adhesion, anchorage, invasion and metastasis, are likely to be important for governing their biological characteristics. A change in the physical properties of mammalian cells could be an indication of disease. In this paper, we present a silicon-nanowire-array based technique for quantifying the mechanical behavior o...

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