نتایج جستجو برای: l11

تعداد نتایج: 680  

Journal: :Blood 1997
L M McEvoy M A Jutila P S Tsao J P Cooke E C Butcher

Recruitment of blood monocytes into tissues is a central event in the inflammatory response and in atherogenesis. The mechanisms leading to monocyte adhesion and migration through endothelium are not completely defined. We recently reported that MAb L11, against the leukocyte sialomucin CD43, blocks T-lymphocyte binding to lymph node and Peyer's patch high endothelial venules (HEV) and inhibits...

Journal: :The EMBO journal 2007
Hasan Demirci Steven T Gregory Albert E Dahlberg Gerwald Jogl

Bacterial ribosomal protein L11 is post-translationally trimethylated at multiple residues by a single methyltransferase, PrmA. Here, we describe four structures of PrmA from the extreme thermophile Thermus thermophilus. Two apo-PrmA structures at 1.59 and 2.3 A resolution and a third with bound cofactor S-adenosyl-L-methionine at 1.75 A each exhibit distinct relative positions of the substrate...

2012
Dandan Zhang Guangqiao Liu Jiaying Xue Jizhong Lou Knud H. Nierhaus Weimin Gong Yan Qin

Translational GTPases (trGTPases) regulate all phases of protein synthesis. An early event in the interaction of a trGTPase with the ribosome is the contact of the G-domain with the C-terminal domain (CTD) of ribosomal protein L12 (L12-CTD) and subsequently interacts with the N-terminal domain of L11 (L11-NTD). However, the structural and functional relationships between L12-CTD and L11-NTD rem...

2017
Seyedardalan Ashrafzadeh David W M Leung

It is of interest to apply plant tissue culture to generate plants resistant to toxic effects of cadmium (Cd) on plant growth. Callus cultures were initiated from leaf explants of micropropagated potato plantlets (Solanum tuberosum L., cv. Iwa) for in vitro selection comprising 18 different Cd treatments varying in Cd exposure timing and duration. Plantlets regenerated from two different lines ...

Journal: :Nucleic acids research 2000
L B Blyn L M Risen R H Griffey D E Draper

Antibiotics that inhibit ribosomal function may do so by one of several mechanisms, including the induction of incorrect RNA folding or prevention of protein and/or RNA conformational transitions. Thiostrepton, which binds to the 'GTPase center' of the large subunit, has been postulated to prevent conformational changes in either the L11 protein or rRNA to which it binds. Scintillation proximit...

2016
Ji Hoon Jung Moon Joon Kim Hyemin Lee Jihyun Lee Jaekwang Kim Hyun Joo Lee Eun Ah Shin Yoon Hyeon Kim Bonglee Kim Bum Sang Shim Sung-Hoon Kim

Though Farnesiferol c (FC) has been reported to have anti-angiogenic and antitumor activity, the underlying antitumor mechanism of FC still remains unclear. Thus, in the present study, we investigated the apoptotic mechanism of FC in human H1299 and H596 non-small lung cancer cells (NSCLCs). FC significantly showed cytotoxicity, increased sub-G1 accumulation, and attenuated the expression of Bc...

Journal: :The Biochemical journal 2006
Takaomi Nomura Kohji Nakano Yasushi Maki Takao Naganuma Takashi Nakashima Isao Tanaka Makoto Kimura Akira Hachimori Toshio Uchiumi

We cloned the genes encoding the ribosomal proteins Ph (Pyrococcus horikoshii)-P0, Ph-L12 and Ph-L11, which constitute the GTPase-associated centre of the archaebacterium Pyrococcus horikoshii. These proteins are homologues of the eukaryotic P0, P1/P2 and eL12 proteins, and correspond to Escherichia coli L10, L7/L12 and L11 proteins respectively. The proteins and the truncation mutants of Ph-P0...

Journal: :Nucleic acids research 1995
M Lu D E Draper

Ribosomal protein L11 and an antibiotic, thiostrepton, bind to the same highly conserved region of large subunit ribosomal RNA and stabilize a set of NH4(+)-dependent tertiary interactions within the domain. In vitro selection from partially randomized pools of RNA sequences has been used to ask what aspects of RNA structure are recognized by the ligands. L11-selected RNAs showed little sequenc...

Journal: :Reproductive BioMedicine Online 2010

Journal: :Reports in Mechanical Engineering 2022

Microchannels are important devices to improve the heat exchange in several engineering applications as heat, ventilation and air conditioning, microelectronic cooling, power generation systems others. The present work performs a numerical study of microchannel with two trapezoidal blocks subjected laminar flows, aiming analyze influence boiling process on geometric configuration microchannel. ...

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