Methionine is a protective factor against various types of liver damage, but excessive dietary methionine is hepatotoxic. Because the mechanisms of L-methionine-related hepatotoxicity are poorly understood, the effect of long-term excessive L-methionine intake on the metabolism of iron and antioxidants was studied in rat liver to determine whether oxidative stress is involved. Wistar male rats ...

Soriano-Garcı́a, Juan F., Mònica Torras-Llort, Miquel Moretó, and Ruth Ferrer. Regulation of L-methionine and L-lysine uptake in chicken jejunal brush-border membrane by dietary methionine. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1654–R1661, 1999.—In the chicken intestine, L-methionine is transported by systems that are specific for neutral amino acids (Land B-like) and ...

BACKGROUND L-Methionine potentiates systemic hemodynamic effects of intravenous glyceryl trinitrate (GTN) in tolerant and nontolerant patients to a similar extent as N-acetylcysteine (NAC). This potentiation of GTN action by L-methionine has been attributed to enhanced intracellular formation of nitrosothiols, known to be potent stimulators of soluble guanylyl cyclase. This study was performed ...

Catabolism of L-methionine by Escherichia coli strain B SPAO led to the formation of ethylene as a secondary metabolite (ethylenogenesis). Methionine was initially deaminated by a transamination reaction to the 2-oxo acid 2-oxo-4-methylthiobutyric acid (KMBA) which was then converted to ethylene. The utilization of L-methionine as an additional nitrogen source was investigated by examining ethy...

The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...

1. L-[U-14C]methionine was used to study methionine metabolism in sheep fed on untreated silage, silage treated with formaldehyde and untreated silage plus intraperitoneal infusion of L-methionine. 2. Over-all the values ranged from 0.43 to 0.86 mmol/h for methionine turnover rate, from 13.3 to 19.9 for the percentage of methionine oxidized to carbon dioxide and from 245 to 1089 mumol for methi...

In the chicken intestine,l-methionine is transported by systems that are specific for neutral amino acids (L- and B-like) and by systems that can also transport cationic amino acids (y+m and b0,+-like). These four uptake pathways have been investigated in brush-border membrane vesicles from the jejunum of chickens fed a diet enriched with 0.4%l-methionine. Methionine supplementation from the 1s...

Yarrowia lipolytica is one of the yeasts most frequently isolated from the surface of ripened cheeses. In previous work, it has been shown that this yeast is able to convert L-methionine into various volatile sulfur compounds (VSCs) that may contribute to the typical flavors of several cheeses. In the present study, we show that Y. lipolytica does not assimilate lactate in the presence of L-met...

Abstract Stability and structure of complexes between silver (I) l -methionine (L) deduced from potentiometric 1 H NMR measurements allow to assume the prevailing several protonated species. The experimental data are compatible with formation following complexes: AgL, AgL 2 , AgH L, L 3 4 . coordination sites obtained by spectra, showing that only bond methylthioether sulfur atom is responsible...

Methionine dependency has been reported in cancer cell lines and primary tumors. Thus, L-methionine deprivation might have potential value for the treatment of human cancers with a methionine requirement. L-Methionine-a-deamino-'y-mercaptomethane-lyase has been reported to decrease plasma methionine levels and to inhibit tumor growth in exper imental animals but has not been studied extensively...