Extraction of positive and negative ions from a saddle antenna radio-frequency surface plasma source (SA RF SPS) is considered. Several versions of new plasma generators with different antennas and magnetic field configurations were tested in the small Test Stand. The efficiency of positive ion generation in plasma has been improved up to 80 times from 2.5 mA/cm kW to ~0.2 A/cm per 1 kW. For ce...

This study evaluates the pulsed tunable dye laser with wavelength 504 nm, frequency 10 Hz, and pulse width 1.2 microseconds for cholelitholysis. Power of 10-40 kW was directed through a 250-microns quartz fiber optic to ablate 55 gallstones (removed from 14 patients). The fiber was positioned in direct contact with the stones under saline. Power delivery was begun at 10 kW and increased in 10-k...

To study the mechanisms involved in the progression of meiotic maturation in the mouse, we used oocytes from two strains of mice, CBA/Kw and KE, which differ greatly in the rate at which they undergo meiotic maturation. CBA/Kw oocytes extrude the first polar body about 7 hours after breakdown of the germinal vesicle (GVBD), whilst the oocytes from KE mice take approximately 3-4 hours longer. In...

OBJECTIVES This study sought to evaluate the dose-dependent effects of adenosine A1-receptor blockade on diuresis and renal function in patients with acute decompensated heart failure (ADHF) and renal impairment or diuretic resistance. BACKGROUND Intravenous loop diuretics are the mainstay of therapy for patients with ADHF. Treatment, however, may be complicated by diuretic resistance and/or ...

Anaerobic co-digestion technology is increasingly used to simultaneously treat solid and liquid organic waste to balance nutrient content, to reduce the negative effects of toxic compounds in the process, and to increase biogas yield. The aim of this study was to analyze the economic performance of co-digestion plants fed with agro-industrial wastes as a function of installed power, with a meth...

In this study, the application of microwave treatment for wood plasticisation and its densification for flooring system purposes is presented. Microwave plasticisation was carried out using a continuous laboratory device at a frequency of 2.45 GHz, and the testing samples made from European beech (Fagus sylvatica L.) wood were plasticised at different power modes (2 kW, 3.5 kW, and 5 kW). After...

Introduction Changes in the exchange rate of water across the blood-brain barrier (BBB), denoted kw, may indicate BBB dysfunction before the leakage of larger molecules, such as contrast agents, is observable. One approach for measuring kw is to combine diffusion-weighted (DW) imaging with arterial spin labelling (ASL) to measure the vascular and tissue fractions of labelled water (1,2). kw is ...

Numerous solid tumors overexpress or have excessively activated insulin-like growth factor receptor-1 (IGF-1R). We summarize preclinical studies and the first-in-human study of KW-2450, an oral tyrosine kinase inhibitor with IGF-1R and insulin receptor (IR) inhibitory activity. Preclinical activity of KW-2450 was evaluated in various in vitro and in vivo models. It was then evaluated in a phase...

Many studies demonstrate a high accuracy for PET in staging lymphoma, but few assess observer variation. This study quantified agreement for staging lymphoma with PET/CT. Methods: The PET/CT images of 100 patients with lymphoma who had been referred for staging were reviewed by 3 experienced observers, with 2 observers reviewing each series a second time. Ann Arbor stage and individual nodal an...