a Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan b Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan c Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Shinjuku-ku, Tokyo Japan d Divisi...

Central Laboratories for Key Technologies, Kirin Co., Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan (N.U.); RIKEN Center for Sustainable Resource Science, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan (N.U., K.O., K.S.); Graduate School of Agricultural Science, Kobe University, Nada-ku, Kobe, Hyogo 657-8501, Japan (M.N., M.M.); Department of Chemistry and Materials Science, Tokyo Institute o...

RIKEN Plant Science Center, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan (Y.S.-S., Y.J., Y.K., K.S.); Graduate School of Information Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8579, Japan (T.O.); Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa 226-8501, Japan (H.S.); Center for Biological Resources and Informatics, To...

Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates of anti-Ku antibodies in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of single-specificity anti-K...

all tumor cells are created equal when it comes to telomere biology. Tumor cells that do not express telomerase appear to utilize a telomerase-independent process to maintain telomere length, known as ALT for alternative lengthening of telomeres [1]. Although the existence of this process has been recognized for some time, the precise mechanism by which telomeres are maintained in these cells h...

the quality traits of triticum dicoccoides ku-13441 (triticum turgidum l. var. dicoccoides (aabb, 2n= 4x= 28)) were analyzed by mixograph, and the results showed that t. dicoccoides ku-13441 had desirable qualities in gluten strength and flour stirring tolerance. subsequently, seventeen novel full-orf α-gliadin genes and thirty-five pseudogenes were cloned and sequenced from t. dicoccoides ku-1...

The Ku antigen is a heteromeric (Ku70/Ku80), mostly nuclear protein. Ku participates in multiple nuclear processes from DNA repair to V(D)J recombination to telomere maintenance to transcriptional regulation and serves as a DNA binding subunit and allosteric regulator of DNA-dependent protein kinase. While some evidence suggests that subcellular localization of Ku may be subject to regulation, ...

The binding of the Ku protein to DNA was investigated using the atomic force microscope. Ku was found to bind predominantly to the ends of double-stranded DNA. Experiments with plasmid DNA revealed that Ku does not bind to circular plasmids but does bind to plasmids that have been linearized by treatment with ionizing radiation. The binding of Ku to poly(dG-dC) x poly(dG-dC) polynucleotides and...