نتایج جستجو برای: krebs cycle
تعداد نتایج: 276207 فیلتر نتایج به سال:
BACKGROUND The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess site-specific label incorporation into a range of metabolite pools, including malate, aspartate and...
13C NMR of isotopically enriched metabolites has been used to study the metabolism of Microbacterium ammoniaphilum, a bacterium which excretes large quantities of L-glutamic acid into the medium. Biosynthesis from 90% [1-13C]glucose results in relatively high specificity of the label, with [2,4-13C2]glutamate as the major product. The predominant biosynthetic pathway for synthesis of glutamate ...
Introduction In normal hearts, Krebs cycle flux is maintained by continuous citrate synthase-mediated condensation of acetyl-CoA with oxaloacetate. In turn, acetylCoA is produced from the oxidation of fatty acids, ketone bodies or glucose, via glycolysis and the enzyme pyruvate dehydrogenase (PDH). Hyperpolarised [2C]pyruvate has been used in the isolated heart to observe the relationship betwe...
PURPOSE The energy-yielding mitochondrial Krebs cycle has been shown in many cancers and other diseases to be inhibited or mutated. In most cells, the Krebs cycle with oxidative phosphorylation generates approximately 90% of the adenosine triphosphate in the cell. We designed and hyperpolarized carbon-13 labeled succinate (SUC) and its derivative diethyl succinate (DES) to interrogate the Krebs...
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