Lead concentration in muscle, liver, kidney, brain and gonad tissues of two cyprinid fishes, Cyprinus carpio and Copoeta spp., from three sections of the upper, middle and lower parts of the Kor River was evaluated in 2006. Totally 225 specimens were caught for this purpose (75 specimens from each zone). Tissue samples were digested in acid and their lead concentrations were assayed by ICP meth...

Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly understood.We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal μand κ-opioid receptors (MOR and KOR, respectively). This finding suggests an interrelationship between MOR and KOR in females that is not manifest in males. Here,we sho...

mRNA of opioid receptor (KOR) can be transported to nerve fibers, including axons of dorsal root ganglia (DRG), and can be locally translated. Yeast three-hybrid screening identifies Copb1 as a kor mRNA-associated protein that form complexes with endogenous kor mRNA, which are colocalized in the soma and axons of DRG neurons. Axonal transport of kor mRNA is demonstrated, directly, by observing ...

Psychotomimetic and prodepressive effect by kappa opioid receptor (KOR) activation in rodents and human is widely known. Significantly, recent clinical investigations demonstrated the salutary effects of KOR antagonists in patients with treatment resistant depression, indicating essential role of KOR signaling in refractory depression. This study was undertaken to reveal the molecular determina...

the iranian persian chub is an endemic species of the family cyprinidae known only from few localities in drainages of southern iran. it was originally described in the genus pseudophoxinus as (pseudophoxinus persidis) and then petroleuciscus (as petroleuciscus persidis). in this study, we examined phylogenetic relationships of the iranian persian chubwith other relatives in the family cyprinid...

every year the entrance of factory wastes such as shiraz petrochemical complex, marvdasht sugar cube factory, and charmineh factory, and other industrial units into the kor and sivand rivers and also the entrance of the marvdasht and zarghan city sewer system wastes into the kor river and the use of their water in the cultivation of the rice has caused a significant increase in the lead and cad...

Epidermal growth factor (EGF), a mitogen, also stimulates neurite extension during development, but the underlying mechanism is elusive. This study reveals a functional role for kappa opioid receptor (KOR) in EGF-stimulated neurite extension, and the underlying mechanism. EGF and activated EGF receptor (EGFR) levels are elevated in embryonic spinal cords during late gestation stages, with concu...

We previously demonstrated that the spinal cord κ-opioid receptor (KOR) and μ-opioid receptor (MOR) form heterodimers (KOR/MOR). KOR/MOR formation and the associated KOR dependency of spinal morphine antinociception are most robust during proestrus. Using Sprague Dawley rats, we now demonstrate that (1) spinal synthesis of estrogen is critical to these processes, and (2) blockade of either estr...

Lead concentration in muscle, liver, kidney, brain and gonad tissues of two cyprinid fishes, Cyprinus carpio and Copoeta spp., from three sections of the upper, middle and lower parts of the Kor River was evaluated in 2006. Totally 225 specimens were caught for this purpose (75 specimens from each zone). Tissue samples were digested in acid and their lead concentrations were assayed by ICP meth...