Brinker is the key target protein of the Drosophila Decapentaplegic morphogen signalling pathway. Brinker is widely expressed and can bind with DNA. NMR spectra suggest that apo-Brinker is intrinsically unstructured and undergoes a folding transition upon DNA-binding. However, the coupled mechanism of binding and folding is poorly understood. Here, we performed molecular dynamics (MD) simulatio...

Divergence date estimates are central to understand evolutionary processes and depend, in the case of molecular phylogenies, on tests of molecular clocks. Here we propose two non-parametric tests of strict and relaxed molecular clocks built upon a framework that uses the empirical cumulative distribution (ECD) of branch lengths obtained from an ensemble of Bayesian trees and well known non-para...

Signal detection performance in cognitive radio architecture is enhanced by the cooperation of sensing detectors if the fading and shadowing effects exist on the channel. A cooperative spectrum sensing technique in cognitive radio networks based on two-sample Kolmogorov-Smirnov test is proposed in this paper and proposed sensing scheme is examined under Rician fading channel. The performance of...

In statistics, two-sample tests are used to determine whether two samples have been drawn from the same population. A widely used test as such is the Kolmogorov-Smirnov two-sample test. There are other distribution-free tests which might be applied in similar occasions. In this article, we describe a two-sample omnibus test introduced by Epps and Singleton, which has – albeit being distribution...

In symbolic data analysis, the values of the variables can be, among others, intervals. The algebraic structure of these variables leads us to adapt dissimilarity ones to be able to study them. The Kolmogorov-Smirnov criterion is used as a test selection metric for decision tree induction. For this criterion, the values taken by the explanatory variables have to be ordered. We have been interes...