Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It predominately affects the nasal mucosa but can also involve the rest of the upper respiratory tract. The well-known causative agent for rhinoscleroma is the bacterium Klebsiel...

Arylamine N-acetyltransferase activity has been described in various bacterial species. Bacterial N-acetyltransferases, including those from bacteria of the gut flora, may be involved in the metabolism of xenobiotics, thereby exerting physiopathological effects. We characterized these enzymes further by steady-state kinetics, time-dependent inhibition, and DNA hybridization in 40 species, mostl...

Abstract Rhinoscleroma is a chronic infectious condition found mainly in patients living underdeveloped regions. It affects the respiratory tract (in 95% of cases nasal cavity first affected), but it can also involve orbit, middle ear, lip, gums and cutaneous tissue. linked to infection with Klebsiella rhinoscleromatis. Females are far more frequently affected than males. Symptoms typically app...

Rhinoscleroma is a chronic, granulomatous infectious lesion most frequently affecting the respiratory tract mucosa. This disease is endemic to Africa, Central and South America, South Central and Eastern Europe, the Middle East, and China. We report an extremely rare disease of nasal rhinoscleroma in Korea. The patient was a 63-yr-old man, who suffered from chronic nasal obstruction and septal ...

Respiratory scleroma (often termed ‘rhinoscleroma’) is a chronic inammatory condition in which deforming masses of tissue distend the nasal cavity. Klebsiella rhinoscleromatis is the causative agent of this infection and the Mikulicz cell is speciŽc to the lesion being a large macrophage with clear cytoplasm containing the bacilli. Antibiotic therapy has traditionally consisted of streptomycin...

SYNOPSIS Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for identification. K. aerogenes is the type most commonly isolated from all...

Rhinoscleroma is a progressive, granulomatous infectious disease, usually limited to the upper respiratory tract and produced by Klebsiella rhinoscleromatis 1,2 . Sporadic cases and endemic foci of the disease have been found in 68 countries 3,4 . Clinically, the disease has been described in progressive stages; however overlapping of the stages occur frequently in the individual patient 3,5-7 ...

Klebsiella pneumoniae is found in the environment and as a harmless commensal, but is also a frequent nosocomial pathogen (causing urinary, respiratory and blood infections) and the agent of specific human infections including Friedländer's pneumonia, rhinoscleroma and the emerging disease pyogenic liver abscess (PLA). The identification and precise definition of virulent clones, i.e. groups of...