Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of injury in specific regions of the nephron is incompletely understood. Our study aimed to use existing urinary biomarkers to describe the pattern of kidney injury and proteinuria in pregnancies affected by severe preeclampsia. We performed a case-control study of pregnant women from Brigham and Women's ...

ABSTRACT Background Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive and specific urinary biomarker for kidney injury. Blood KIM-1 was recently associated with the severity of acute chronic damage but its value in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis glomerulonephritis (ANCA-GN) ...

Abstract Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney molecule-1 (KIM1) is dramatically upregulated in renal tubules upon injury, acts as a biomarker for various diseases. However, the exact role underlying mechanism of KIM1 progression AKI remain elusive. Herein, we report that tubular specific knockout Kim1 attenuates cisplatin- or ischemia/reperfusion-induced male ...

Abstract Background and Aims Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive, specific urinary biomarker for kidney injury. Blood KIM-1 was recently associated with the severity of acute chronic damage but its value in ANCA-associated vasculitis glomerulonephritis (ANCA-GN) has not been studied. Thus, we ana...

Complex Information for Anesthesiologists Presented Quickly and ClearlyCPB, cardiopulmonary bypass; IGFBP7, insulin-like growth factor binding protein 7; IL-18, interleukin-18; KDIGO, Kidney Disease: Improving Global Outcomes; KIM-1, kidney-injury- molecule-1; NGAL, neutrophil gelatinase-associated lipocalin; TEE, transesophageal echocardiography; TIMP-2, tissue inhibitor of metalloproteinase 2...