BACKGROUND Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are present. We describe a live kidney slice model in which pericyte-mediated vasa recta constriction/dilation can be visualized in situ. METHODS Confo...

The present study was performed to determine the role of afferent arterioles in the impaired autoregulatory response shown to occur in the contralateral kidney of Goldblatt hypertensive rats. The responsiveness of juxtamedullary afferent arterioles to alterations in perfusion pressure was studied in the nonclipped kidney of two-kidney, one clip hypertensive and sham-operated rats. Systolic pres...

Defects in the development or maintenance of tubule diameter correlate with polycystic kidney disease. Here, we report that absence of the cadherin regulator p120 catenin (p120ctn) from the renal mesenchyme prior to tubule formation leads to decreased cadherin levels with abnormal morphologies of early tubule structures and developing glomeruli. In addition, mutant mice develop cystic kidney di...

A congenital solitary kidney with multiple renal arteries is a rare congenital abnormality that can occur in the presence of multiple other anomalies. We describe an atypical case of a right congenital solitary kidney with three renal arteries (RA) one main RA and two additional renal arteries in a 75-year-old woman with uterine didelphys. The main RA had an intraluminal diameter larger than th...

a true estimation of gestational age (ga) plays an important role in quality maternity care and scheduling the labor date. this study aimed to evaluate the normal fetal kidney length (kl) and its correlation with ga. a cross-sectional study on 92 pregnant women between 8th and 10th week of gestation with normal singleton pregnancy underwent standard ultrasound fetal biometry and kidney length m...

phenol is widely used in numerous non prescription products and the aim of present study was to investigate the dose- dependent effects of phenol on morphometrical and histometrical changes of kidney in an animal model. for this experiment, 60 adult female balb/c mice were weighed, and categorrzed as one control and three experimental groups of 15 individuals each. control group, received only ...

BACKGROUND This study aimed to compare the changes in kidney function and the association of tumor size and renal outcomes between patients with renal cell carcinoma (RCC) who underwent radical nephrectomy (RN) and those who underwent partial nephrectomy (PN). METHODS A retrospective cohort study was conducted for 557 patients with an RCC of ≤7 cm in diameter and normal contralateral kidney f...

urtica dioica l. is an iranian native pharmacological plant for which little attention has been paid to the anatomical structure. medical applications of this plant include diabetes therapy, digestive improvement, anemia and kidney disease therapy. because climatic conditions can affect the anatomical structure which in turn affects pharmacological compositions, research on the anatomy of this ...