Oocytes undergo a range of complex processes via oogenesis, maturation, fertilization, and early embryonic development, eventually giving rise to a fully functioning organism. To understand proteome composition and diversity during maturation of human oocytes, here we have addressed crucial aspects of oocyte collection and proteome analysis, resulting in the first proteome and secretome maps of...

Abstract Study question Are there genetic mutations which may lead to recurrent failures of assisted reproductive technology? Summary answer In this study, some genes were found be candidates for causing repeated ART failures. What is known already Although aging one the greatest hindrances successful pregnancy, many patients remain infertile, enduring failures, and approximately 20% infertilit...

Maternal effect genes control early events of embryogenesis. Maternal homozygous and compound mutations in two such genes, NLRP7 and c6orf221, have been detected in the majority of women experiencing recurrent biparental hydatidiform moles. It was suggested that other forms of reproductive wastage, including diploid androgenetic moles, partial moles, polyploidy, recurrent spontaneous abortions ...

The eight publications in the November issue of the journal (one review and seven original articles) are all about pregnancy. To some of our readers this will be a surprise—there is a popular myth that Molecular Human Reproduction (MHR) loses interest in reproduction after implantation. The papers we publish this month demonstrate that this just is not true.We consider scientific reports on top...