نتایج جستجو برای: khartooran erg

تعداد نتایج: 7132  

Journal: :Molecular cancer research : MCR 2013
Rajareddy Singareddy Louie Semaan M Katie Conley-Lacomb Jason St John Katelyn Powell Matthew Iyer Daryn Smith Lance K Heilbrun Dongping Shi Wael Sakr Michael L Cher Sreenivasa R Chinni

UNLABELLED CXCR4 is a chemokine receptor that mediates invasion and metastasis. CXCR4 expression is transcriptionally regulated in cancer cells and is associated with aggressive prostate cancer phenotypes. Previously, we and others have shown that the transcription factor ERG regulates CXCR4 expression in prostate cancer cells and that androgens modulate CXCR4 expression via increasing ERG expr...

Journal: :The Prostate 2014
Aaron M Udager Yang Shi Scott A Tomlins Ajjai Alva Javed Siddiqui Xuhong Cao Kenneth J Pienta Hui Jiang Arul M Chinnaiyan Rohit Mehra

BACKGROUND ERG rearrangements in localized prostate cancer can be detected with high sensitivity and specificity by immunohistochemistry (IHC). However, recent data suggest that ERG IHC may be less sensitive for ERG rearrangements in castration-resistant prostate cancer (CRPC). Thus, we sought to examine ERG protein expression in a cohort of rapid autopsy patients with lethal metastatic CRPC (m...

2014
Liliana H. Mochmann Martin Neumann Eva K. von der Heide Verena Nowak Anja A. Kühl Jutta Ortiz-Tanchez Juliane Bock Wolf K. Hofmann Claudia D. Baldus

Overexpression of the oncogene ERG (ETS-related gene) is an adverse prognostic factor in acute myeloid and T-cell lymphoblastic leukemia (AML and T-ALL). We hypothesize that ERG overexpression is associated with primary drug resistance thereby influencing the outcome in leukemia. We previously reported a cell-line based model of ERG overexpression which induced a potentially chemo-resistant spi...

2010
Ahmed A. Mohamed Shyh-Han Tan Natallia Mikhalkevich Sathibalan Ponniah Valeri Vasioukhin Charles J. Bieberich Isabell A. Sesterhenn Albert Dobi Shiv Srivastava Taduru L. Sreenath

Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light of its suggested role in cell differentiation and proliferation. Here, we analy...

Journal: :Cancer research 2011
Ram-Shankar Mani Matthew K Iyer Qi Cao J Chad Brenner Lei Wang Aparna Ghosh Xuhong Cao Robert J Lonigro Scott A Tomlins Sooryanarayana Varambally Arul M Chinnaiyan

Recurrent gene fusions involving ETS family genes are a distinguishing feature of human prostate cancers, with TMPRSS2-ERG fusions representing the most common subtype. The TMPRSS2-ERG fusion transcript and its splice variants are well characterized in prostate cancers; however, not much is known about the levels and regulation of wild-type ERG. By employing an integrative approach, we show tha...

2016
Eliska Potuckova Jan Zuna Lenka Hovorkova Julia Starkova Jan Stary Jan Trka Marketa Zaliova

Intragenic ERG deletions occur in 3-5% of B-cell precursor acute lymphoblastic leukemia, specifically in B-other subtype lacking the classifying genetic lesions. They represent the only genetic lesion described so far present in the majority of cases clustering into a subgroup of B-other subtype characterized by a unique gene expression profile, probably sharing a common, however, not yet fully...

2016
Parameet Kumar Shashwat Sharad Gyorgy Petrovics Ahmed Mohamed Albert Dobi Taduru L. Sreenath Shiv Srivastava Roopa Biswas

Epigenetic regulation by SIRT1, a multifaceted NAD+-dependent protein deacetylase, is one of the most common factors modulating cellular processes in a broad range of diseases, including prostate cancer (CaP). SIRT1 is over-expressed in CaP cells, however the associated mechanism is not well understood. To identify whether specific microRNAs might mediate this linkage, we have screened a miRNA ...

2013
Sudhir Rawal Denise Young Molly Williams Monica Colombo Raghunath Krishnappa Gyorgy Petrovics David G. McLeod Shiv Srivastava Isabell A. Sesterhenn

INTRODUCTION AND OBJECTIVE ERG oncogene fusions (predominantly TMPRSS2-ERG) represent the most common (50-70% frequency) and validated prostate cancer (CaP) genome alteration in the Western countries. A common TMPRSS2-ERG fusion type leads to the androgen dependent tumor cell specific expression of the TMPRSS2-ERG fusion transcript and amino terminally truncated ERG oncoprotein. CaP prevalence ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Sarah Minner Malaika Enodien Hüseyin Sirma Andreas M Luebke Antje Krohn Pascale S Mayer Ronald Simon Pierre Tennstedt Julia Müller Laura Scholz Jan C Brase Alvin Y Liu Hartmut Schlüter Klaus Pantel Udo Schumacher Carsten Bokemeyer Thomas Steuber Markus Graefen Guido Sauter Thorsten Schlomm

PURPOSE About 50% of prostate cancers have TMPRSS2-ERG fusions with concurrent ERG overexpression. The aim of this study was to determine whether clinical differences exist between ERG-positive and ERG-negative cancers in surgically treated patients not exposed to antihormonal therapy. A secondary aim was to search for differences between these tumor classes. EXPERIMENTAL DESIGN A tissue micr...

2010
Albert Dobi Bungo Furusato Syed Shaheduzzaman Yongmei Chen Maryanne Vahey Timothy Nydam Isabell A. Sesterhenn David G. McLeod Gyorgy Petrovics Shiv Srivastava

Expression of the ERG proto-oncogene, is activated in 50-70% of prostate tumors by androgen receptor (AR) mediated signals due to the fusion of AR regulated promoters (primarily TMPRSS2 and to a lesser extent SLC45A3 and NDRG1) to the ERG protein coding sequence. Our previous studies of quantitative expression levels of ERG or TMPRSS2-ERG fusion transcripts have noted that relatively low or no ...

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