First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Chaitali Khan is the first author on ‘The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster’, published in Journal of Cell Science. Chaitali ...

The history of Tow–Thomas second-order filter is reviewed. Two alternative generation methods of the Tow–Thomas filter are discussed. The first is a generation method from the second-order passive RLC filter and the second is from the multiple feedbacks inverting low-pass filter using a single op amp. Several forms of the circuit are briefly reviewed. Passive and active compensation methods to ...

The true slime mold Physarum polycephalum, a single-celled amoeboid organism, is capable of efficiently allocating a constant amount of intracellular resource to its pseudopod-like branches that best fit the environment where dynamic light stimuli are applied. Inspired by the resource allocation process, the authors formulated a concurrent search algorithm, called the Tug-of-War (TOW) model, fo...

Pain is a life-long symptom in sickle cell disease (SCD) and a predictor of disease progression and mortality, but little is known about its molecular mechanisms. Here, we characterized pain in a targeted knockin mouse model of SCD (TOW mouse) that exclusively expresses human alleles encoding normal α- and sickle β-globin. TOW mice exhibited ongoing spontaneous pain behavior and increased sensi...

In today's mixed-model assembly production, there are two recent trends in particular, namely increasing vertical integration and the proliferation of product variety, which more and more shift focus to an e cient just-in-time part supply. In this context, many automobile manufacturers set up decentralized logistics areas referred to as supermarkets . Here, small tow trains are loaded with part...

The sea surface temperature (SST) and enthalpy flux response to tropical cyclones (TCs) in the Kuroshio are investigated using 18-year observational datasets. statistical results show that maximum TC-induced SST cooling its occurrence time, recovery spatial patterns of anomaly, anomaly between warm core eddies (WCEs) typical oceanic water (i.e., eddy-free Kuroshio-free, TOW) varies considerably...

The delayed failure time of SiC-based multifilament tows under static fatigue condition is as broadly scattered for individual filaments, despite it commonly used strong scatter reduction. Moreover, the stress exponent (n) hierarchy-dependent revealed by a Monte-Carlo algorithm: decreasing from filament (micro) scale to tow (meso) scale. This demonstrated originate mismatch between applied crit...