During renal failure, abnormalities of BCAA and branched-chain keto acid (BCKA) metabolism are due to both the lack of renal contribution to amino acid metabolism and the impact of renal failure and acidosis on whole-body nitrogen metabolism. Abnormal BCAA and BCKA metabolism result in BCAA depletion as reflected by low plasma BCAAs and cellular valine. BCAA metabolic disturbances can alter tis...

Straightforward conversion of (+)-6,8-dimethoxy-3,4-dihydro-3- undecylisocoumarin (3) to the title isocoumarin was carried out. Hydrolytic ring opening of (3) afforded the hydroxy acid (4) which was immediately oxidized to keto acid (5) using chromic acid, Cyclodehydration of (5) afforded the 6,8- dimethoxy-3-undecylisocoumarin (6) which on selective demethylation of 8- methoxy group furni...

The main challenge of effectively managing emergencies in diabetic ketoacidosis (DKA) is the fine tuning of the treatment in order to re-establish the normal metabolic homeostasis. We propose a mobile application for clinical decision support in DKA emergencies (mDKA), running under Android on smart phones and tablet PCs. mDKA provides decision support for treatment concerning the main componen...

Purpose. The aim of this study was to investigate the association between prostanoid [thromboxane (TxA2) and prostacyclin (PGI2)] levels in synovial fluid infrapatellar fat pad (IPFP)/ suprapatellar (SPFP) thickness as well other clinical findings knee steoarthritis (OA) patients.
 Materials Methods: 16 patients with OA effusion were included. average pain evaluated using a Visual Analogue...

OBJECTIVE The present study is undertaken to evaluate the magnitude of DKA in Saudi population with specific emphasis on clinical laboratory characteristics over 20 years. MATERIAL AND METHODS A prospective analysis of hospital records of 240 episodes of DKA requiring inpatient admission from December 1985 to December 2005 in adult patients in a tertiary hospital was performed. Besides the de...

straightforward conversion of (+)-6,8-dimethoxy-3,4-dihydro-3- undecylisocoumarin (3) to the title isocoumarin was carried out. hydrolytic ring opening of (3) afforded the hydroxy acid (4) which was immediately oxidized to keto acid (5) using chromic acid, cyclodehydration of (5) afforded the 6,8- dimethoxy-3-undecylisocoumarin (6) which on selective demethylation of 8- methoxy group furnished ...

fecl3.6h2o was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in etoh at room temperature. the remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. the structures o...