Keratinocyte growth factor (KGF) belongs to the fibroblast growth factor (FGF) family, and its activity seems to be restricted to epithelial cells. It elicits its biological effects through binding to the KGF receptor (KGFR), a splicing transcript variant of FGF receptor 2 (FGFR2). The presence of multiple isoforms of FGFR2 and the overlapping specificities of the FGFs with respect to their rec...

background: extensive full-thickness burns require replacement of both epidermis and dermis. in designing skin replacements, the goal has been to re-create this model and make a product which has both essential components. methods: in the present study, we developed procedures for establishing confluent, stratified layers of cultured human keratinocytes on the surface of modified collagen-chito...

Abbreviations: 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyl ethyl ammonium bromide, (DMRIE); activation protein-1, (AP-1); Basement membranes, (BM); colony stimulating factor (CSF), dioleoylphosphatidyl ethanolamine, (DOPE); fibroblast growth factor, (FGF); growth hormone, (GH); Hepatocyte growth factor, (HGF); insulin-like growth factor-I, (IGF-I); interleukin-1, (IL-1); interleukin-6, (IL-6); ...