Psoriasis is a chronic inflammatory skin disorder characterized by rapid proliferation of keratinocytes and incomplete keratinization. Discovery of safer and more effective anti-psoriatic drugs remains an area of active research at the present time. Using a HaCaT keratinocyte cell line as an in vitro model, we had previously found that ethanolic extracts from three Thai medicinal herbs, namely ...

The mechanisms of progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EA) are not known. Cycloxygenase2 (COX-2)-derived prostaglandin E2 (PGE2) has been shown to be important in esophageal tumorigenesis.We have shown that COX2 mediates acid-induced PGE2 production. The prostaglandin E synthase (PGES) responsible for acid-induced PGE2 production in BE, however, is not known. ...

In human-aware planning, a planning agent may need to provide an explanation human user on why its plan is optimal. A popular approach do this called model reconciliation, where the tries reconcile differences in and human's such that also optimal model. paper, we present logic-based framework for reconciliation extends beyond realm of planning. More specifically, given knowledge base KB1 entai...

Bcl-3 is an atypical member of the IkB family and modulates gene expression via interaction with p50/NF-kB1 or p52/NF-kB2 homodimers. We report in the present study that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow–derived DCs blunted their ability to expand and promote effector functions of T cells upon Ag/adjuvant ...

Weed populations of sprangletop (Leptochloa chinensis) such as Kampung Permetang (KP), Kampung Pida-Tiga (KPT), Sungai Baru (SB1 and SB2), Kampung Pida-Empat (KPE), Singkir Yan (SY), Tanjung Dawai (TD), Dulang Besar (DB) and Kampung Bahagia (KB1 and KB2) were collected from paddy (Oryza sp.) growing areas in Kedah, Malaysia to identify resistant biotypes and their method of control. Weed biotyp...

Chitinase cDNAs from Leucaena leucocephala seedlings were cloned by PCR amplification with degenerate primers based on conserved class I chitinase sequences and cDNA library screening. Two closely related chitinase cDNAs were sequenced and inferred to encode precursor proteins of 323 (KB1) and 326 (KB2) amino acids. Expression of the KB2 chitinase from a pET32a plasmid in Origami (DE3) Escheric...