BACKGROUND Corpora amylacea (CAm) are a hallmark of aging and neurodegeneration. The presence of kynurenine aminotransferases I and II (KAT I and II) in CAm in the human retina and optic nerve has been already shown. The present study aimed to examine kynurenine aminotransferase III (KAT III) immunoreactivity in CAm in the human retina and optic nerve. MATERIAL AND METHODS Polyclonal antibody...

Kleene algebra (KA) is the algebra of regular events. Familiar examples of Kleene algebras include regular sets, relational algebras, and trace algebras. A Kleene algebra with tests (KAT) is a Kleene algebra with an embedded Boolean subalgebra. The addition of tests allows one to encode while programs as KAT terms, thus the equational theory of KAT can express (propositional) program equivalenc...

George Gkinis1,5*, Constantinos Mourouzis4, Panayotis Dais1, Aristea Velegraki2 and George Rallis3 1Trainee in Oral and Maxillofacial Surgery Department, General Hospital of Attica, KAT, Athens, Greece 2Assistant Professor in Mycology Laboratory, Department of Microbiology, Medical School, University of Athens, Greece 3Director Oral and Maxillofacial Surgeon, Head of the Department, KAT, Athens...

The endogenous neuroinhibitory amino acid receptor antagonist kynurenic acid (KYNA) has been hypothetically linked to physiological processes and to the pathogenesis of several brain disorders. The aim of this study was to search KYNA metabolism i.e. KYNA levels and enzymes synthesising KYNA kynurenine aminotransferase I and II (KAT I and II) in the central nervous system (CNS) and in the perip...

Lysine acetyltransferases (KATs) play a critical role in the regulation of gene expression, metabolism, and other key cellular functions. One shortcoming of traditional KAT assays is their inability to study KAT activity in complex settings, a limitation that hinders efforts at KAT discovery, characterization, and inhibitor development. To address this challenge, here we describe a suite of cof...

Kleene algebra with tests (KAT) is an equational system for program verification, which is the combination of Boolean algebra (BA) and Kleene algebra (KA), the algebra of regular expressions. In particular, KAT subsumes the propositional fragment of Hoare logic (PHL) which is a formal system for the specification and verification of programs, and that is currently the base of most tools for che...

The Karoo Array Telescope (KAT) will be a “1% demonstrator” for the SKA, located in a radio quiet reserve in the Karoo region of the Northern Cape province of South Africa. Besides developing technologies for the SKA project, the KAT will perform wide-field surveys that will be precursors to the eventual SKA products. The nominal specification for the KAT are listed, and the proposed science th...

Trimetazidine acts as an effective antianginal clinical agent by modulating cardiac energy metabolism. Recent published data support the hypothesis that trimetazidine selectively inhibits long-chain 3-ketoacyl CoA thiolase (LC 3-KAT), thereby reducing fatty acid oxidation resulting in clinical benefit. The aim of this study was to assess whether trimetazidine and ranolazine, which may also act ...

A B S T RA C T The effects of vasoconstrictor-receptor (neuropeptide Y, a-adrenergic, serotonergic, histaminergic) stimulation on currents through ATP-sensitive potassium (KATe) channels in arterial smooth muscle cells were examined. Whole-cell KAT e currents, activated by the synthetic KAT e channel opener pinacidil or by the endogenous vasodilator, calcitonin gene-related peptide, which acts ...

Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay aging and that when mutated cause premature aging (progeria). To seek such genes, we performed a genetic screen for C. elegans mutants that age pr...