The effects of cAMP-analogue dibutyryl-cAMP and anticalmodulin W-7 were studied on de novo synthesis and secretion of lipids in cultures of hepatoma McArdle RH7777 cells and normal rat hepatocytes. Dibutyryl-cAMP and W -7 separately caused a significant decrease in the secretion of de novo synthesized triacyl [3H]glycerol in both cultures of McArdle cells and rat hepatocytes. The inhibito...

Since the original description of Rift Valley fever in sheep, cattle and man in the Rift Valley in Kenya in 1931, very little has been published on the disease in cattle. This report deals with the macroscopic and microscopic pathology of field cases of Rift Valley fever in 22 adult cattle, 8 calves and 8 aborted foetuses. The microscopic liver lesions in 13 adult cattle were characterized by m...

We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat. Methods: Rats were given following treatments daily for 30 d: Group A: Control Group B: Rats received cypermethrin Group C: These rats received cypermethrin and Jamun seed extract simultaneously Group D: These rats received cypermethrin and orange peel extract simultaneou...

the effects of camp-analogue dibutyryl-camp and anticalmodulin w-7 were studied on de novo synthesis and secretion of lipids in cultures of hepatoma mcardle rh7777 cells and normal rat hepatocytes. dibutyryl-camp and w -7 separately caused a significant decrease in the secretion of de novo synthesized triacyl [3h]glycerol in both cultures of mcardle cells and rat hepatocytes. the inhibitory eff...

high levels of regulated oncogen-alpha (gro-a) expression have been observed in the liver. gro-a stimulates proliferation of epithelial cells and induction of rolling and extravascular migration of neutrophils and mononuclear cells. given the above observations, this chemokine was chosen to be analyzed in freshly isolated and cultured hepatocytes. in this study, hepatocytes (2×106 cell/ml) were...

SUMMARY Some effects of l-@3-D-arabinofuranosylcytosine and of 1-13-D-arabinofuranosyl-5-fluorocytosine on normal prolifer ating tissues in rat are described. l-j3-D-Arabinofuranosylcyto sine at doses 1/30 the @ causes marked and transient inhibition of the incorporation oflabeled thymidine into DNA of small intestine, spleen, thymus, and regenerating liver and induces karyorrhexis in epithelia...

alkaloids of the aerial parts of chelidonium were extracted in the salt form, and their aqueous solutions were prepared in different concentrations. rat hepatocytes were obtained by liver perfusion. the alkaloidal solutions were added to suspensions of hepatocytes in petri dishes and the mixtures were incubated. two types of controls have been used in one type. no alkaloidal extract was added t...

lead (pb), has, for decades, being known for its adverse effects on various body organs and systems. in the present study, the damage of pb on the liver tissue apoptosis was investigated, and lycopersicon esculentum as an antioxidants source was administered orally to prevent the adverse effects of pb. eighteen wistar rats, randomized into three groups (n=6), were used for this study. animals i...

background hepatocytes are used as an in vitro model to evaluate drug metabolism. human hepatocyte transplant has been considered as the temporary treatment of acute liver failure. optimization freezing methods is very important to preserve both cell viability and function which are achieved by cryopreservation mostly always. objectives the present study aimed to investigate the cryoprotective ...