A novel category of phosphate-phosphonate compounds is synthesized by a sequence multicomponent reactions strategy Kabachnik-Fields and Atherton-Todd reactions. All the designed products are obtained with good chemical yields in short reaction times, confirmed spectroscopy analyses. The diethyl [(4-diethylphosphate phenyl) (4-trifluoromethyl phenylamino) methyl] phosphonate 6g characterized sin...

An efficient method for the synthesis of a new series α-aminophosphonates has been developed in one-pot Kabachnik-Fields reaction 4-methylaminophenol with various aldehydes and triethylphosphite under microwave irradiation neat conditions using ZnO nanoparticles as reusable heterogeneous catalyst, 82-93% yield at 250 Hz within 2-5 min. A single crystal studied compound 3e was selected X-ray dif...

In this research article, 2,3-trimethylene-3,4-dihydrobenzo[2,3-d]pyrimidin-4-one was synthesized from 2-aminobenzoic acid and pyrrolidone-2 in the presence of various substances, such as PCl5, POCl3. Its reduction reaction with NaBH4 carried out. The resulting three-component coupling 2,3-trimethylene-1,2,3,4-tetrahydrobenzo[2,3-d]pyrimidin-4-one-carbonyl, amine, hydrophosphoryl leads to αamin...

Samples of layered double hydroxides were prepared by a sol-gel procedure. Quinolinate Al(C9H6NO)3 units were added during the synthesis, leading to composite quinolinate hydrotalcite-like compounds. The amount of quinolinate was varied, showing that the number of organic building blocks determines the physicochemical properties of materials, which differ significantly from those commonly repor...

Objective: The present studies discuss the anticancer activity of different topoisomerase II inhibitors with docking study.
 Methods: work reports synthesis novel diethyl (4-oxo-4H-chromen-3-yl)(5-substituted phenyl-1,3,4-thiadiazol-2-ylamino)methyl phosphonate derivatives 6(a-j). They were synthesized through one-pot three-component Kabachnik-Fields reaction by using ultrasonicator proces...

background: airport workers are continuously exposed to different levels of radiofrequency microwave (rf/mw) radiation emitted by radar equipments. radars are extensively used in military and aviation industries. over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile ...