Background & Objective:  Acute lymphoblastic leukemia (ALL) is a malignant disease that arises from various mutations in B or T-lymphoid progenitors. MicroRNAs (miRNAs) regulate gene expression by binding to the 3' untranslated region of protein-coding genes. Dysregulation of miRNA expression m...

Abstract In this paper, the bovine serum albumin protected gold nanozymes (BSA-Au nanozymes) were utilized as a novel nanodrug for treatment of acute T-type lymphoblastic leukemia (Jurkat) by production excessive ROS and effect on expression anti-apoptotic genes. The BSA-Au Bcl-2 survivin in Jurkat cell line was checked. results showed that genes significantly reduced after with (p-value 0.001)...

HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that Nef can be transferred to neighboring cells and alters the function of these cells. However, how the intercellular Nef transfer occurs is in dispute. In the current study, we attempted to address this important issue using several complementary strategies, a panel ...

background: absent in melanoma 2 (aim2) is an intracellular microbial dsdna sensor which plays an important role in production of proinflammatory cytokines through apoptosis associated speck-like protein containing a caspase activation and recruitment domain (asc) and caspase-1. micro-rnas (mirnas) play important roles in regulation of immune related genes. however, there is little information ...

BACKGROUND Fisturalines are bromotyrosine compounds isolated from marine sponges. Previous studies have shown antineoplasic, antiviral and antibacterial effects in Vitro; however, the possible effects of these compounds in hematologic malignancies have not been assessed. METHODS In the present study, the antiproliferative and pro apoptotic effects of Fistularin-3 (F) and 11-Deoxyfistularin-3 ...

To isolate a stable tumor cell line capable of producing human interleukin 2 (IL-2; formerly referred to as T cell growth factor), 16 human T and B leukemia cell lines were screened for constitutive and mitogen-stimulated IL-2 production. We found that the T cell leukemia line designated Jurkat-FHCRC produced > 200 U/ml of IL-2 activity after a 24-h stimulation with T cell mitogens. Peak mitoge...

background: several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (mscs) in allogeneic or mitogenic interactions. cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. objective: to investigate if adipose derived mscs could inhibit jurkat lym-phoblastic leukemia t cell proliferation during coculture. me...

Cells of the proerythromyeloid cell line K562 and of the T cell line Jurkat were able to induce an increase in TNF-, IL1 alpha-, and IL1 beta-mRNA expression in human peripheral blood derived monocytes in vitro. The activating principle of these tumor cells was associated with fractions of membrane preparations of distinct molecular mass, 32-38 kD for Jurkat cells and 46-54 kD for K562 cells, r...

Notch signaling, which is driven by the Notch1 receptor, plays an essential role in the pathogenesis and stroma-mediated drug resistance of T-cell acute lymphoblastic leukemia (T-ALL). However, little is known about the roles of Notch ligands in the survival or drug resistance of T-ALL cells. In the present study, isolated mesenchymal stem cells (MSCs) from human umbilical cord (hUC) samples, t...