Although heavy metals are naturally occurring elements that found throughout the Earth’s crust, most environmental contamination and human exposure result from anthropogenic activities, such as mining smelting operations, industrial production use, domestic agricultural use of metal-containing compounds. The accumulation eventually produces reactive oxygen species can cause oxidative stress, wh...

BACKGROUND Juglans regia has been found to exhibit significant anticancer activity against various human cancer cell lines. This study was undertaken to isolate the active chemical constituent (Juglone) and to investigate its cytotoxic activity along with its various analogs against different human cancer cell lines. METHODS Isolation of juglone, a napthoquinone, from the chloroform extract o...

continued on page 4 The term allelopathy was first introduced in 1937 and refers to biochemical interactions among plants that alters plant growth, including those mediated by microorganisms. Allelopathy, besides including competition for resources among plants, is considered to be an important mechanism of plant interference caused by the addition of plant-produced toxins to the plant environm...

Atherosclerosis, as a chronic inflammatory disease, is the major underlying cause of death worldwide. However, the mechanisms that underlie the inflammatory process are not completely understood. Prolyl-isomerase-1 (Pin1), as a unique peptidyl-prolyl isomerase, plays an important role in inflammation and endothelial dysfunction. Herein, we investigate whether Pin1 regulates vascular inflammatio...

In the present study, an appropriate synthetic route was adopted to produce the target synthesis of Juglone. In the first of these objectives, 5-nitro-1,4-naphthoquinone had been synthesized by direct nitration of 1,4-naphthoquinone in the presence of water and sulfuric acid. Then the intermediate synthesis of 5-amino-1,4-naphthoquinone was obtained by the reduction of nitro. Finally, Juglone w...

Objectives We aimed to investigate the effects of juglone on angiogenesis, metastasis and cell proliferation processes in pancreatic cancer (PC) understand whether its possible occur via Wnt signaling pathway by analyzing expression levels target genes signaling. Background PC is a silent lethal type which can only be detectable after angiogenesis occured. The one pathways that plays an active ...

Organic selenium compounds possess numerous biological properties, including antioxidant activity. Yet, the high toxicity of some of them, such as diphenyl diselenide (DPDS), is a limiting factor in their current usage. Accordingly, we tested four novel organic selenium compounds in the non-parasite nematode Caenorhabditis elegans and compared their efficacy to DPDS. The novel organic selenium ...

BACKGROUND Prostate cancer initially develops in an androgen-dependent manner but, during its progression, transitions to being androgen-independent in the advanced stage. Pin1, one of the peptidyl-prolyl cis/trans isomerases, is reportedly overexpressed in prostate cancers and is considered to contribute to accelerated cell growth, which may be one of the major factors contributing to their an...

Black walnut ( Juglans nigra ) is considered one of the most valuable plants, with a global production 3.5 million tons dried fruit yearly. Throughout past two millennia, its allelopathic effects have been widely recognized. walnuts produce natural naphthoquinone called juglone, which occurs naturally in all parts tree, particularly green husk, and contributes significantly to black walnut. Exc...

In the preceding paper (Daglish, 1950) it was shown that juglone existed in the walnut as the glucoside of 1:4:5-trihydroxynaphthalene and not as free anor P-hydrojuglone as previously suggested (Mylius, 1885a, b). In order to determine its role in the economy ofthe plant, the occurrence ofthe glucoside was determined during the 1948 and 1949 growing periods. The methods used, together with the...