PURPOSE The goals of this study are to elucidate the relationship of the oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) with glioma aggressiveness and to understand the role of high STAT3 activity in the resistance of malignant gliomas and medulloblastomas to chemotherapy. EXPERIMENTAL DESIGN Immunohistochemical staining and biochemical methods were ...

CONFIDENCE Ubiquitous Care System to Support Independent Living is one of the most interesting FP7 projects for The department of intelligent systems at JSI. In this paper we present WP3, the major SW component of the system that is also implemented as two stand-alone versions of the system. In this paper, the two systems are presented from the user viewpoint based on five manuals.

Senior staff members: Position(s): Degrees: E-mail addresses: Jørgen Jespersen Jørgen Gram Else-Marie Bladbjerg Anna-Marie Münster Johannes J. Sidelmann Cornelis Kluft Moniek de Maat Chief physician, Professor Chief physician, Assoc. Prof Assistant Professor Senior registrar Assistant Professor Professor Associate Professor MD, Dr. Med. Sci. MD, Dr. Med. Sci. MSc, PhD MD, PhD PhD PhD, DSc MSc, ...

Background Since 1994, USAID and JSI have provided introductory supply chain courses for international audiences. As demand for these courses continued to grow, it became apparent that local delivery would increase the cost-effectiveness and sustainability of global SCM trainings. Starting in 2007, the USAID | DELIVER PROJECT built the capacity of four Regional Training Institutes (RTIs) that n...

Signaling via Jak2/STAT3 is critically important for normal dendritic cell (DC) differentiation. In addition, we have previously demonstrated that hyperactivation of the Jak2/STAT3 pathway induced by tumor-derived factors (TDF) may be responsible for abnormal DC differentiation in cancer. In this study, using a novel selective inhibitor of Jak2/STAT3, JSI-124, we investigated the mechanism of t...

Abstract. A primary mercury gas standard was developed at Van Swinden Laboratory (VSL) to establish an International System of Units (SI)-traceable reference point for concentrations emission and background levels in the atmosphere. The majority concentration measurements are currently made traceable empirically determined vapour pressure mercury. can be used accurate precise calibration analyt...