conclusions both pca techniques provided effective pain scores (< 3) after cardiac surgery; but generally, pca-paracetamol infusion has a better analgesic effect. results the trend of pain scores did not have any significantly difference between group r and group p except for hour 8 and hour 18 after surgery that vas was significantly lower in group p than group r (p = 0.031, p = 0.023, respect...

....................................................................................................................................6 List of original publications ...................................................................................................7 Abbreviations and defi nitions ................................................................................................8 Int...

This study was carried out to investigate the hepatoprotective effect of the aqueous extract of Kohautia grandiflora on paracetamol induced hepatotoxicity in rats. A total of 20 albino rats of the Wister strain weighing 120-180 g were used for the study. The animals were divided into 4 groups of 5-rats each [I-IV]. Groups I, II and III served as the normal, paracetamol and plant extract control...

BACKGROUND Efficacy of pre-emptive analgesia compared to preventive regimen, managing postoperative pain is still controversial. AIM Evaluating the efficacy of intravenous (IV) paracetamol as pre-emptive analgesia compared to preventive post-treatment administration in pediatric dental setting. DESIGN In a prospective trial, 60 noncooperative children of ASA I, II aged 3-10 years who underw...

BACKGROUND AND OBJECTIVE We compared the efficacy of intravenous (IV) paracetamol versus dipyrone via patient-controlled analgesia (PCA) for postoperative pain relief in children. METHODS The study was composed of 120 children who had undergone elective tonsillectomy after receiving general anesthesia. Patients were divided into 3 groups according to the dosage of postoperative intravenous-pa...

Selection of anesthetic drugs for cesarean section requires many considerations. Anesthetic drugs for this purpose must prevent hemodynamic stress due to tracheal intubation, while inducing neonatal complications. This study was conducted to determine the effects of paracetamol given before induction of anesthesia on cardiovascular responses to tracheal intubation and postoperative pain in the ...

Background and Objective: The cesarean section is one of the most common surgical procedures performed today. Two common complications are pain and bleeding which, if incorrectly controlled, may develop into increased complications. The aim of this research was to compare the effects of diclofenac suppository and intravenous paracetamol on post-cesarean pain and bleeding. Methods and Materials...

OBJECTIVES Because of the extensive variability in paracetamol clearance in young women, published data were pooled with newly collected observations in search of covariates of paracetamol pharmacokinetics (PK) within this specific population. SUBJECTS AND METHODS PK estimates and clinical characteristics [pregnant, weight, exposure to oral contraceptives (OC)] in young women following IV loa...

Ahead of Print article withdrawn by publisher AIM: Intravenous regional anesthesia (IVRA) is frequently used in patients who will undergo upper extremity surgical operations for its ease of use, rapid effectiveness and short hospitalization period. Different drug combinations have been used to overcome some systemic adverse effects and to increase the postoperative analgesic effectiveness. In o...

BACKGROUND The purpose of the present study was to determine the post-operative analgesic effects of preemptive intravenous (iv) paracetamol and the amount of reduction in tramadol (Contramal(®)) consumption. MATERIALS AND METHODS Following local research ethics committee approval, ASAI-II, 300 patients were assigned in a randomized manner into three groups: Group I (preemptive) received iv p...