To evaluate the extent of drug-drug interaction concerning metabolic inhibition in the liver quantitatively, we tried to predict the plasma concentration increasing ratio of midazolam (MDZ) by itraconazole (ITZ) or ketoconazole (KTZ) in rats. MDZ was administered at a dose of 10 mg/kg through the portal vein at 60 min after bolus administration of 20 mg/kg ITZ or during 0.33 mg/h/body of KTZ in...

Itraconazole (ITZ) solid complex using hydroxypropyl-beta-cyclodextrin (ITZ-HP-beta-CD) with 20% polyvinylpyrrolidone was prepared by a co-evaporation method. The complex improved antifungal activity against C. parapasilosis and C. albicans. The complex demonstrated good flow and compressibility characteristics. The complex was formulated as a capsule dosage form and drug release was evaluated....

Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P < 0.05 to 0.0001). At equivalent doses of 50 mg/kg of body weight, RCZ and ITZ were equally effective and RCZ was more effective than FCZ (P = 0.02). Clearance of fungal burden from the livers and splee...

SCH-56592 (SCH) is a novel triazole antifungal agent with excellent in vitro activity against Aspergillus. We compared three doses (5, 10, and 25 mg/kg of body weight) of SCH with itraconazole (ITZ; 25 mg/kg) and amphotericin B (AB; 5 mg/kg) in a temporarily neutropenic murine model of disseminated aspergillosis (lungs and kidneys) against one ITZ-susceptible (AF71) and one ITZ-resistant (AF90)...

Available experimental investigations on the effect of the aggregate-paste ‘interfacial transition zone’ (ITZ) on mass transport properties of cement-based materials appear to be ambiguous. Whilst some studies have found a deleterious effect of the ITZ, results from others seem to suggest otherwise. In the present study, we examined the relative influences of ITZ and microcracking on the oxygen...

In this paper, supercritical carbonation tests of concrete specimens with different water-to-cement ratios are carried out. the test, thickness interfacial transition zone (ITZ) is determined by distribution Ca/Si ratio across interface between coarse aggregate and cement paste. The microhardness distribution, microstructure porosity ITZ before after analyzed. A geometrical physical model consi...

The interfacial transition zone (ITZ) is known to strongly influence the mechanical and transport properties of mortars and concretes. This paper studies the ITZ between siliceous (quartz) aggregates and alkali-activated slag (AAS) binders in the context of mortar specimens. Backscattered electron (BSE) images generated in an environmental scanning electron microscope (ESEM) are used to identif...

A three-dimensional (3D) finite element method (FEM) based on an inserted cohesive numerical analysis procedure was developed for concrete mesoscale systems the ABAQUS platform with python scripts. Aggregates were generated dividing existing geometrical algorithms to randomize arbitrary spheres. Simultaneously, randomizations of maximum aggregate size and uniform distributions particles also co...

The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of ivermectin (IVM), an antiparasitic widely used in human and veterinary medicine. The work included the evaluation of two different P-gp modulators [itraconazole (ITZ) and valspodar (PSC833)] used at equimolar doses in the rat. Furthermore, the influence of both P-gp modulator agent...

Isolates of Aspergillus fumigatus that demonstrate resistance to itraconazole (ITZ) have been described previously; however, the prevalence and clinical significance of ITZ resistance are not completely understood. In this study we assessed the ITZ susceptibilities of 128 A. fumigatus isolates that caused invasive infection in 82 stem cell transplant patients before and after the use of ITZ in ...