We report a case of rare cervical isthmic spondylolisthesis of C6-7 combined occult spinal bifida at C6, and review the radiologic finding, different diagnosis and treatment. A 23-year old female presented nuchal, back pain after traffic accident. Radiologic finding showed the 6(th) cervical isthmic defect, spondylolisthesis and dysplasia. The patient was conservatively treated about 8 weeks, a...

Progressive spondylolisthesis may occur in adults with isthmic spondylolysis with an estimated incidence of 20%. This biomechanical study showed that in adult spines with bilateral L5 pars fractures, an anterior slip of L5 depends on the extent of the load-bearing deficiency of the disc and the presence of shear force across L5-S1. A combination of disc degeneration and muscle dysfunction may b...

This case report describes the first case of a bone bridge formation across the left L5/S1 neuroforamen after instrumented posterolateral fusion for L5/S1 isthmic spondylolisthesis. Our patient was a 70-year-old lady who had grade 2, L5/S1 isthmic spondylolisthesis and bilateral S1 nerve root compression. She suffered from mechanical low back pain and neurogenic claudication, with radicular pai...

Early in development, the behavior of neuroepithelial cells is controlled by several factors acting in a developmentally regulated manner. Recently it has been shown that diffusible factors contained within embryonic cerebrospinal fluid (CSF) promote neuroepithelial cell survival, proliferation, and neurogenesis in mesencephalic explants lacking any known organizing center. In this paper, we sh...

OBJECTIVE To define the potential value of endocervical length at 11 to 13 weeks' gestation in the prediction of spontaneous early delivery. METHOD The lengths of the endocervix and cervico-isthmic complex were measured by transvaginal ultrasound at 11 to 13 weeks in singleton pregnancies, including 1492 that subsequently delivered after 34 weeks and 16 (1.1%) who had spontaneous delivery bef...

In zebrafish acerebellar (ace) embryos, because of a point mutation in fgf8, the isthmic constriction containing the midbrain-hindbrain boundary (MHB) organizer fails to form. The mutants lack cerebellar development by morphological criteria, and they appear to have an enlarged tectum, showing no obvious reduction in the tissue mass at the dorsal mesencephalic/metencephalic alar plate. To revea...

The isthmic organizer, which patterns the anterior hindbrain and midbrain, is one of the most studied secondary organizers. In recent years, new insights have been reported on the molecular nature of its morphogenetic activity. Studies in chick, mouse and zebrafish have converged to show that mutually repressive interactions between the homeoproteins encoded by Otx and Gbx genes position this o...

A 71-year-old woman with isthmic aortic coarctation underwent aortic valve replacement and coronary bypass. Before aortic clamping, end-to-side anastomosis to descending aorta was performed. After cardiac surgery, the graft was directed posterior to the inferior vena cava and anastomosed to the ascending aorta by using a side-biting clamp (Fig. 1). Fig. 1. Three-dimensional computed tomographic...

AIM To describe a modified technique for the treatment of single level, isthmic spondylolisthesis (IS) MATERIAL and METHODS Forty-two patients who underwent posterior lumbar interbody fusion (PLIF) with spinolaminar autologous bone graft for the treatment of isthmic spondylolisthesis between May 2007 and November 2011, were retrospectively reviewed. All patients underwent total removal of the...

BACKGROUND Traditional surgical treatment of isthmic spondylolisthesis is posterior-lateral fusion, but the addition of anterior surgery has been explored. The purpose of this study was to evaluate the surgical and clinical outcomes of anterior-posterior surgical treatment for low-grade isthmic spondylolisthesis. METHODS Retrospectively, we enrolled 23 consecutive patients (mean age of 50) wh...