In the title compound, C(12)H(9)F(3)N(2)O(2), the benzene ring is nearly perpendicular to the isoxazole ring, making a dihedral angle of 82.97 (2)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into a supra-molecular chain running along the c axis.

In the title compound, C16H13NO2, the isoxazole ring makes dihedral angles of 17.1 (1)° with the 3-meth-oxy-phenyl ring and 15.2 (1)° with the phenyl group. Centrosymmetric dimers that are realised by pairs of C-H⋯π inter-actions are observed in the crystal structure.

Amanita muscaria is the most emblematic mushroom in popular representation. It an ectomycorrhizal fungus endemic to cold ecosystems of northern hemisphere. The basidiocarp contains isoxazoles compounds that have specific actions on central nervous system, including hallucinations. For this reason, it considered important entheogenic different cultures whose remnants are still visible some moder...

In the title compound, C(16)H(13)NO, the isoxazole ring makes dihedral angles of 16.64 (7)° with 3-methyl-phenzyl ring and 17.60 (7)° with the unsubstituted phenyl ring.

Background and objective: Five-membered heterocycle compounds having single oxygen nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole have a broad range of biological activities therapeutic value. In view strategic design antimicrobial compounds, several new ester-functionalized isoxazoles were synthesized characterized. Methods: A regioselective isoxazole incorporating an a...

In the title compound, C(17)H(15)N(3)O(4)S, the five-membered isoxazole ring makes dihedral angles of 80.5 (2) and 81.3 (2)° with the two benzene rings, which form a dihedral angle of 39.81 (18)° with each other. A short intra-molecular C-H⋯O contact occurs. The crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds, which generate [001] chains, and further consolidated by weak...

A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described. Stereocontrolled additions of nucleophiles to cyclic nitrones generated the corresponding 2,3-trans adducts, allowing the synthesis of the corresponding pyrrolidines via key intermediates bearing an alkyne and a nitrile oxide. Three hybrid systems, including a pyrrolidine with two isoxazoles and one...

A concise one-pot synthesis of highly functionalized pyridines has been developed. The first step in the reaction sequence is the formal insertion of rhodium vinylcarbenoids across the N-O bond of isoxazoles. Upon heating, the insertion products undergo a rearrangement to give 1,4-dihydropyridines. DDQ oxidation then affords the corresponding pyridines in 31-84% yield. The process has proven ge...