We studied the effects of adenosine and isoproterenol on membrane currents of isolated bovine and guinea pig ventricular myocytes with a two-microelectrode voltage clamp technique. Adenosine (50 microM to 0.2 mM) alone had no effect on any of the membrane currents measured, but it antagonized the effects induced by 10 nM isoproterenol. Peak calcium membrane current was augmented by isoprotereno...

The Israel Resuscitation with Isoproterenol Study included 79 consecutive patients with witnessed out-of-hospital asystolic cardiac arrest who were resuscitated with epinephrine and atropine and randomized to receive additional isoproterenol or no isoproterenol. The rate of return of spontaneous circulation and survival to hospital admission did not differ in patients receiving standard therapy...

UNLABELLED Isoproterenol has been suggested as an alternative marker for epidural test dosing in children receiving halothane anesthesia. The purpose of this prospective, randomized, double-blind study was to determine the chronotropic response to IV isoproterenol in sevoflurane-anesthetized children. Thirty-six ASA physical status I children (0.5-8 yr) were anesthetized with either halothane o...

Myocardial infarction (MI) is a common presentation of the ischemic heart disease. Lavandula angustifolia is a herbaceous plant with antioxidative effects.This study was designed to investigate the cardioprotective effects of lavandula angustifolia essential oil against isoproterenol-induced MI in rats.The dried sample was subjected to hydrodistillation by using a Clevenger and the oils were dr...

Background: Heart failure (HF) has become one of the most prevalent cardiovascular problems worldwide. Considering the beneficial effects of probiotics on human health, we aimed to investigate the anti-inflammatory effect of oral administration of Lactobacillus paracasei in HF induced by isoproterenol. Methods: Forty Wistar male rats weighing 80g on average were randomly assigned to five grou...

The present study was designed to evaluate the effect of quercetin on myocardial oxidative stress and immunity function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Wistar rats were subcutaneously injected with isoproterenol (70 mg/kg). Blood immunity index, cardiac marker enzymes and antioxidative parameters in hearts were measured. It was found that the levels o...

The present study was designed to evaluate the cardioprotective effects of methanolic extract of Litsea deccanensis (MELD) against isoproterenol-induced myocardial infarction in rats by studying cardiac markers, lipid peroxidation, lipid profile, and histological changes. Male Wistar rats were treated orally with MELD (100 and 200 mg/kg) daily for a period of 21 days. After 21 days of pretreatm...

Background and Aims : Hyperactive poly(ADP-ribose) polymerases (PARP) promote ischemic heart failure (IHF) after myocardial infarction (MI). However, the role of Tankyrases (TNKSs), members PARP family, in progression IHF remains unknown. We aimed to explore TNKSs pathophysiological process therapeutic potential TNKS inhibition for IHF.Methods: Cardiac samples from patients MI rats were employe...

Indigofera cassioides Rottl. Ex. DC. is a large shrub, distributed throughout the hills of India. Because its reported robust antioxidant potential and phytoconstituents content, we were interested in investigating vitro thrombolytic vivo cardioprotective effect methanolic leaves extract cassioides. An model was used to evaluate clot lysis different concentrations along with streptokinase as po...

Head-up tilt-table test is valuable in diagnosing type of syncope. Sensitivity varies in reports and is mostly poor. Isoproterenol or nitroglycerin is regularly used to increase head-up tilt-table test sensitivity. The aim of this study was to assess the value of sublingual isosorbide dinitrate administration before isoproterenol tilt test as a simple, practical test for diagnosis of neurally m...