The effects of piretanide and furosemide on systemic arterial blood pressure and heart rate were examined in the anesthetized dog and the effects on atrial rate and contractile force were assessed in isolated atrial muscle perfused with heparinized arterial blood from a donor dog. When piretanide was administered intravenously to intact dogs, the depressor and bradycardic responses were produce...

To study synthesis, storage, and secretion of brain natriuretic peptide (BNP) in the heart, we have measured BNP mRNA and BNP concentrations in the hearts of Wistar-Kyoto rats and also have investigated its secretion from the isolated perfused heart. The atrium expressed the BNP gene at a high level, and a considerable amount of BNP mRNA also was present in the ventricle, which corresponded to ...

To study synthesis, storage, and secretion of brain natriuretic peptide (BNP) in the heart, we have measured BNP mRNA and BNP concentrations in the hearts of Wistar-Kyoto rats and also have investigated its secretion from the isolated perfused heart. The atrium expressed the BNP gene at a high level, and a considerable amount of BNP mRNA also was present in the ventricle, which corresponded to ...

Effect of tetrodotoxin (TTX) on the aconitine-induced arrhythmias of the isolated cardiac tissues of the chicken embryo, the toad and the golden carp is studied by a microelectrode technique. TTX in a dose of 10-8-10-7 g/ml antagonized the aconitine-induced rapid firing in the chicken embryo ventricle, the toad atrium and the golden carp atrium. TTX was much more potent than lidocaine in exerti...

When dilazep was administered intravenously to the anesthetized donor dog, mean systemic blood pressure was dose dependently decreased. At a dose of 0.1 mg/Kg i.v., the mean blood pressure was not changed but a slight decrease in heart rate was usually observed in the donor dog. At the same time, a slight but significant decrease in atrial rate and developed tension of the isolated atrium was i...

Introduction Atrial fibrillation (AF) is rare in patients after orthotopic heart transplantation (OHT) and most commonly has been described in the setting of acute rejection or transplant vasculopathy. The principal reason postulated for the rarity of AF after OHT is the fact that the pulmonary veins and posterior left atrial (LA) wall are isolated as a direct result of the left atrioatrial ana...