introduction: vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify immunohistochemical changes that occur in the pancreatic beta ([pancreatic islet beta]) cells of vanadyl sulphate (vs) treated stz induced diabetic rats. materials and methods: male wistar rats were made diabetic with injecting a single intr...

objective(s):some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. incidence of these condition increases with aging. on the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (nos) activity is also altered in diabetes. in this study, modification in the enzyme activity associated with aging a...

histomorphologic and histomorphometric studies on the pancreas of mehraban male sheep were done in four age groups: fetus, neonate, young adult and old age in this respect, we used special stainings, light microscope and ocular micrometer. the results showed that the smooth muscles were absent in capsule. the tubular portion of exocrine pancreas was more prominent. neuroinsular complex and beta...

Transplantation of pancreatic islets represents a clinical therapeutic option to preserve and/or restore b-cell function in patients with diabetes (1,2). The source of the islets is the patient’s own pancreas (autologous, islet autotransplantation [IAT]) when the goal is preserving pancreatic endocrine function in pediatric and adult individuals undergoing total pancreatectomy due to pancreatit...

Objective(s): The use of a co-culture of islets with mesenchymal stromal cells (MSCs) is a promising therapy in islet transplantation to revert hyperglycaemia, but the resulting insulin-producing cells (IPCs) express low levels of pancreas endocrine developmental genes. This study aims to investigate the morphochronology of a co-culture of islets with MSCs from injured adult pancreata, and char...

obesity as a common health risk is increasing all over the world. the aim of this study was evaluation of standing and sitting positions on spirometric values in obese asthmatic patients, in comparison with normal obese subjects. the study included 49 obese asthmatic patients with mean age of 42.63 years and body mass index of 36.06 kg/m 2 , and 51 control obese normal subjects with mean age of...