نتایج جستجو برای: isatin

تعداد نتایج: 789  

2007
Alexei Medvedev Olga Buneeva Vivette Glover

Isatin and its metabolites are constituents of many natural substances. They are also components of many synthetic compounds exhibiting a wide range of effects, including antiviral activity, antitumor and antiangiogenic activity, antibacterial, antitubercular, antifungal, antiaptotic, anticonvulsant and anxyolytic activities. Isatin itself is an endogenous oxidized indole with a wide spectrum o...

2012
Mariappan Premanathan Srinivasan Radhakrishnan Kumarasamy Kulangiappar Ganesan Singaravelu Velayutham Thirumalaiarasu Thangavel Sivakumar Kandasamy Kathiresan

BACKGROUND & OBJECTIVES Derivatives of isatin are known to have cytotoxicity against human carcinoma cell lines. This compound therefore, has a potential to be used as a chemotherapeutic agent against cancer. This study was done to investigate the antioxidant and anticancer activities of isatin, extracted from flower of a folklore medicinal plant Couroupita guianensis against human promylocytic...

Journal: :Molecules 2017
Pavol Tisovský Róbert Šandrik Miroslav Horváth Jana Donovalová Juraj Filo Martin Gáplovský Klaudia Jakusová Marek Cigáň Róbert Sokolík Anton Gáplovský

Five isatin anions were prepared by deprotonation of initial isatins in aprotic solvents using basic fluoride and acetate anions (F- and CH₃COO-). The F- basicity is sufficient to deprotonate isatin NH hydrogen from all the studied compounds. This process is reversible. In the presence of proton donor solvents, the anions form the corresponding isatins. The isatin hydrogen acidity depends on th...

Journal: :Molecules 2008
María Sol Shmidt Ana María Reverdito Lautaro Kremenchuzky Isabel Amalia Perillo María Mercedes Blanco

We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried out under different conditions, always employing methodologies compatible with MW assisted chemistry. Generation of isatin anion employing diverse bases and solvents or using the preformed isatin sodium salt was tested. The best res...

2014
Cen Xiang Dan Wu Luyao Wang Hanrui Wu Bin Lu Ziyin Zhang Yuping Li Yang Liu Rusheng Zhu Ying Jin Yuou Teng Hua Sun

Our previous research have identified a series of N-phenyl substituted isatin derivatives as antitumor agents in vitro. 5-Bromo isatin derivatives have been found to increase their cytotoxic activity and selectivity. A series of 5-bromo-N-phenyl isatin analogues were designed and synthesized about 40-80% overall yields. All of synthesized compounds have not been reported before. Their structure...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه رازی - دانشکده علوم 1390

برهمکنش dna تیموس گاوی با isatin و دو مشتق سنتزی آن , isatin-?-thiosemicarbazone, ibt isonicotinylhydrazone(iinh) isatin-3- در ph فیزیولوژیکی مطالعه شد. برهمکنش ها با طیف سنجیuv-vis،طیف سنجی فوتومتری، آزمایشات رقابتی، دورنگ نمایی دورانی، تکنیک ویسکوزیمتری مطالعه شد. هیچ جابجایی قرمز و نقطه ایزوبستیک در طیف های جذبی مرئیisatin مشاهده نشد. یک واکنش خاموش شدن قوی فلوئوسانس isatin با dna مشاهده شد...

Journal: :iranian journal of pharmaceutical research 0
a patel s bari g talele j patel m sarangapani

some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

Journal: :Bioorganic & medicinal chemistry 2011
Clarina I Manley-King Jacobus J Bergh Jacobus P Petzer

Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform with (E)-5-styrylisatin being the most potent inhibitor. To further investigate these structure-activity relationships (SAR), in the present study, additional C5- and C6-subst...

Journal: :Bioorganic chemistry 2014
Mahesh S Majik Cheryl Rodrigues Stacey Mascarenhas Lisette D'Souza

Marine organisms such as seaweeds, sponges and corals protect their own surfaces from fouling by their high anesthetic, repellant, and settlement inhibition properties. Within the marine ecosystem, evolution has allowed for the development of certain antifouling properties. Isatin is a biologically active chemical produced by an Alteromonas sp. strain inhibiting the surface of embryos of the ca...

Journal: :Organic & biomolecular chemistry 2014
Christina T Lollar Katherine M Krenek Kevin J Bruemmer Alexander R Lippert

An exceptionally mild method for the preparation of isatin derivatives has been developed using a sulfur ylide mediated carbonyl homologation sequence starting from anthranilic acid precursors. This method proceeds at ambient temperature via a sulfur ylide intermediate without the need for protection of the amine or chromatographic isolation of the intermediate ylide. Gentle oxidation of the su...

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