Interactions between calcium-activated chloride channel anoctamin 1 (ANO1) and transient receptor potential vanilloid 1 (TRPV1) enhance pain sensations in mice, suggesting that ANO1 inhibition could have analgesic effects. Here we show that menthol and the menthol analogue isopropylcyclohexane (iPr-CyH) inhibited ANO1 channels in mice. The iPr-CyH derivative 4-isopropylcyclohexanol (4-iPr-CyH-O...

When mice were given a single injection of isoproterenol (IPR), the salivary gland cells were stimulated to enter DNA synthesis in a fairly synchronous manner after a lag period of about 18 hr. 7-ray irradiation of these cells in the early prereplicative phase effectively inhibited the stimulation of DNA synthesis caused by IPR. However, irradiation in the late prereplicative phase or in mid-DN...

By reacting IPr⋅InBr3 with AgSbF6 in dichloroethane at room temperature, we could obtain single crystals comprising [{(IPr⋅InBr3 )(Ag⋅(CH2 Cl)2 )}2 ][SbF6 ]2 (1) and two identical HSbF6 units. It is presumed that the reaction gave rise to [IPr⋅InBr3-x ][SbF6 ]x (x=1, 2, or 3) which reacted with adventitious water to give HSbF6 and [IPr⋅InBr3-x (OH)][SbF6 ]x-1 . The experiment was reproduced at ...

This paper aims at overcoming several shortcomings of previous empirical studies on the relationship between IPR protection and FDI. First, FDI is analyzed on a sectorally and regionally disaggregated level. Second, we address the proposition that stronger IPR protection raises not only the quantity, but also the quality of FDI. Third, we check to which extent the relationship between IPR prote...

When mice were given a single injection of isoproterenol (IPR), the salivary gland cells were stimulated to enter DNA synthesis in a fairly synchronous manner after a lag period of about 18 hr. 7-ray irradiation of these cells in the early prereplicative phase effectively inhibited the stimulation of DNA synthesis caused by IPR. However, irradiation in the late prereplicative phase or in mid-DN...

With the advent of the knowledge economy, knowledge is the principal economic asset and its management and protection have become the cornerstones of an organization strategy. Due to the increasing importance of knowledge, private firms and public institutions such as universities, colleges and research institutes have discovered the importance of protecting and managing their intellectual prop...

Using a difference-in-difference approach, we study how intellectual property right (IPR) protection affects innovation in China in the years around the privatizations of state-owned enterprises (SOEs). Innovation increases after SOE privatizations, and this increase is larger in cities with strong IPR protection. Our results support theoretical arguments that IPR protection strengthens firms’ ...

Reduction of an N-heterocyclic carbene (NHC) adduct of SnCl(2), viz. [(IPr)SnCl(2)] (IPr = :C{N(Dip)C(H)}(2); Dip = 2,6-diisopropylphenyl), with a magnesium(I) dimer, has afforded the first NHC complex of a row 5 element in its diatomic form, [(IPr)Sn=Sn(IPr)]; a computational analysis of the complex indicates that it comprises a singlet state, doubly bonded tin(0) fragment, :Sn=Sn:, datively b...