We discuss the networking dimension of the Integrated Platform for Autonomic Computing (IPAC). IPAC supports the development and running of fully distributed applications that rely on infrastructureless (ad-hoc) network with multi-hop transmission capabilities. Such environment is typically used for the realization of collaborative context awareness where nodes with sensors “generate” and repor...

Shigella invades epithelial cells by inducing cytoskeletal reorganization localized at the site of bacterial-host cell interaction. During entry, the Shigella type III secretion apparatus allows the insertion of a pore that contains the IpaB and IpaC proteins into cell membranes. Insertion of this complex is thought to allow translocation of the carboxy-terminus moiety of IpaC, but also of othe...

A facile, sustainable method for the selective modification of aliphatic hydroxy (R–OH) groups in Kraft lignin was developed using an ionic liquid, 1-ethyl-3-methylimidazolium acetate (EmimOAc), as a solvent and catalyst. Selective R–OH achieved by one-pot, two-step homogeneous reaction: (i) acetylation aromatic OH (Ar–OH) with isopropenyl (IPAc) acyl donor (ii) subsequent deacetylation generat...

background: recombinant vaccine technology is one of the most developed means in controlling infectious diseases. however, an effective vaccine against shigella is still missing. objective: to evaluate recombinant ipac protein of shigella as a vaccine candidate. methods: in this study we cloned ipac gene into an expression vector in prokaryotic system. the protein expression was evaluated by sd...

Burkholderia pseudomallei is an intracellular bacterial pathogen and the causative agent of melioidosis, a severe disease of humans and animals. Like other clinically important Gram-negative bacteria, fundamental to B. pseudomallei pathogenesis is the Bsa Type III Secretion System. The Bsa system injects bacterial effector proteins into the cytoplasm of target host cells subverting cellular pat...

An important challenge in software development is to have efficient tools for creating, debugging, and testing software components developed for specific business domains. This is more imperative if it is considered that a large number of users are not familiar with popular programming languages. Hence, Application Creation Environments (ACEs) based on specific Domain-Specific Languages (DSLs) ...

Introduction Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk,...

Introduction Conclusions References

The products of the ipaB, ipaC, and ipaD genes are involved in the expression of the invasive phenotype in all species of Shigella and enteroinvasive Escherichia coli (EIEC). DNA probes derived from these genes are accurate indicators of the invasive phenotype (M. Venkatesan, J. M. Buysse, E. V. Vandendries, and D. J. Kopecko, J. Clin. Microbiol. 26:261-266, 1988); however, spontaneous loss of ...