The activity of the cardiac Na(+)/Ca(2+) exchanger (NCX1.1) undergoes continuous modulation during the contraction-relaxation cycle because of the accompanying changes in the electrochemical gradients for Na(+) and Ca(2+). In addition, NCX1.1 activity is also modulated via secondary, ionic regulatory mechanisms mediated by Na(+) and Ca(2+). In an effort to evaluate how ionic regulation influenc...

Omelchenko, Alexander, Ron Bouchard, Sabin Shurraw, Michael Trac, Mark Hnatowich, and Larry V. Hryshko. Frequencydependent regulation of cardiac Na /Ca exchanger. Am J Physiol Heart Circ Physiol 289: H1594–H1603, 2005. First published June 10, 2005; doi:10.1152/ajpheart.01094.2004.—The activity of the cardiac Na /Ca exchanger (NCX1.1) undergoes continuous modulation during the contraction-relax...

The activity of the cardiac Na +-Ca 2+ exchanger (NCX1.1) undergoes continuous modulation during the contraction/relaxation cycle due to the accompanying changes in the electrochemical gradients for Na + and Ca 2+. In addition, NCX1.1 activity is also modulated via secondary, ionic regulatory mechanisms mediated by Na + and Ca 2+. In an effort to evaluate how ionic regulation influences exchang...

In present research work, homogeneous anion exchange membranes based on polysulfone (QAPSFs) were prepared via chloromethylation, amination and alkalization. In amination step, trimethylamine and N,N,N',N'-tetramethyl-1,6-hexanediamine were used as amination and crosslinking agents, respectively. The chloromethylated polysulfone was characterized by 1HNMR spectroscopy and chloromethylation degr...

SUMMARY Prior to consideration of the effects of digitalis compounds on ionic exchange the basic mechanisms of active Na+ and K+ transport are discussed. It is generally accepted that digitalis is a specific inhibitor of the Na+-K+ activated ATPase located primarily in the sarcolemmal membrane. Present evidence supports the concept that positive inotropic effects of digitalis are not seen unles...

Transient homodimer protein interactions have been investigated by analyzing the influence of ionic strength (NaCl) on the electron self-exchange (the bimolecular reaction whereby the two oxidation states of a redox protein interconvert) rate constant (k(ese)) of four plastocyanins. The k(ese) values for the plastocyanins from spinach, Dryopteris crassirhizoma (a fern), and the green alga Ulva ...

A place exchange reaction between 11-mercaptoundecanoic acids (MUA) and cetyltrimethylammonium bromide (CTAB)-protected gold nanorods (GNRs) was conducted inside an ionic exchange resin; this modification resulted in functional gold nanorods soluble in both polar and nonpolar organic solvents.