the ip3r calcium release channel has been simulated using a stochastic simulation algorithm (ssa;gillespie algorithm) and de young-keiser model. a set of different concentration for cat' and ip3 havebeen used. considering the number of molecules in each state, a non linear behavior of the system can beseen clearly. the inhibiting role of the ca+2 on the open state (x110) has been studied. the d...

objective: catsper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. catsper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility. in this study, we have explored targeting of the extracellular loop as an approach for the generation of antibodies with the potential ability to b...

Field Effect Diode (FED)s are interesting device in providing the higherON-state current and lower OFF–state current in comparison with SOI-MOSFETstructures with similar dimensions. The impact of channel length and band-to-bandtunneling (BTBT) on the OFF-state current of the side contacted FED (S-FED) has beeninvestigated in this paper. To find the lowest effective channel length, this device i...

PURPOSE We examined the possible role of H(+) activated acid-sensing ion channels in pain perception. We characterized expression in bladder dome biopsies from patients with bladder pain syndrome and controls, in cultured human urothelium and in urothelial TEU-2 cells. MATERIALS AND METHODS Cold cut biopsies from the bladder dome were obtained in 8 asymptomatic controls and 28 patients with b...

A discrete rate theory for general multi-ion channels is presented, in which the continuous dynamics of ion diffusion is reduced to transitions between Markovian discrete states. In an open channel, the ion permeation process involves three types of events: an ion entering the channel, an ion escaping from the channel, or an ion hopping between different energy minima in the channel. The contin...