PURPOSE Intraoperative electron beam radiation therapy (IOERT) involves a modified strategy of conventional radiation therapy and surgery. The lack of specific planning tools limits the spread of this technique. The purpose of the present study is to describe a new simulation and planning tool and its initial evaluation by clinical users. METHODS AND MATERIALS The tool works on a preoperative...

PURPOSE To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). METHODS AND MATERIALS Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 20...

Objectives. The aim of this prospective phase II study is to evaluate the treatment of early-stage breast cancer (T1 N0) with intraoperative electron radiation therapy (IOERT) in terms of local control, early complications, and cosmesis. Patients and Methods. From February 2010 to February 2012, 200 patients underwent partial IOERT of the breast. Inclusion criteria were unifocal invasive ductal...

Purpose Intraoperative radiation therapy (IORT), delivered by intraoperative electron beam (IOERT) or high-dose-rate brachytherapy (HDR-IORT), may reduce the local recurrence rate in patients with locally advanced and recurrent rectal cancer (LARC LRRC, respectively). The aim of this study was to compare oncological outcomes between both IORT modalities LARC LRRC who underwent a microscopic irr...

Background: Intraoperative radiation therapy (IORT) is a novel approach to breast cancer (BC) treatment. Objectives: In this study, we compared the cellular and molecular effects of IORT-treated post-lumpectomy wound fluid (seroma) at point IOeRT versus IOxRT on BC cell line. Methods: Immortalized human lines: MCF-7, MDA-MB-231, MCF10 were incubated with seroma from 3 groups patients (as pilot ...

OBJECTIVE To evaluate the safety, cosmesis, and clinical outcome of intraoperative electron radiation therapy (IOERT) delivered prior to lumpectomy for early-stage breast cancer. METHODS From December 2008 to March 2012, 75 breast cancer patients (ages 34-66 years) were treated with IOERT during breast conservative surgery. IOERT was delivered using a mobile linear accelerator. Suitable energ...

BACKGROUND When a soft tissue sarcoma (STS) is located at the distal part of an extremity and involves the tendon, a wide excision usually causes severe functional disability. We therefore developed a minimally invasive surgical technique using intraoperative electron-beam radiotherapy (IOERT) to reduce the incidence of post-operative functional disability in patients with peri-/intra-tendinous...

Introduction: Intraoperative radiotherapy is a radiotherapy technique in which a high single fraction of radiation dose is delivered to the patient after surgery and Concurrent with anesthesia time. The most frequent method for IORT implementation is Intraoperative electron radiotherapy (IOERT), in which, some dedicated and high dose per pulse electron accelerators are employe...

Radiotherapy techniques permit to deliver ionizing radiations (X-rays, photons, electrons, protons, etc) inside cancerous tissues to kill the abnormal-cells. Radiotherapy related activities, as the optimization of the therapeutic radiation dose to the patient, worker radioprotection, performance controls and technical innovations of linear accelerators, are strongly based on the ability to pred...

Introduction: Intraoperative electron radiotherapy (IOERT) is an IORT technique in which electron beams with different nominal energies are used for irradiation of microscopic residual of tumor bed after surgery. Application of a shielding disk, which is positioned under the target volume, for protecting the normal tissues such as pectoral muscle, lung, and heart is one of the a...