introduction: endoscopy is an invasive and painful procedure in children. since children can not tolerate pain and stress, sedation is necessary in pediatric endoscopy. the aim of this study was comparison of propofol versus intravenous midazolam for reducing anxiety in children.   materials and methods: in this study, 103 patients (2-14 years old) in whom endoscopy was indicated were divided i...

BACKGROUND State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and withdrawal symptoms including cognitive deficits. Therefore, we aimed to inv...

OBJECTIVE to compare clinical and cost effectiveness of midazolam and diazepam for urgent intubation. METHODS patients admitted to the Central ICU of the Santa Casa Hospital Complex in Porto Alegre, over the age of 18 years, undergoing urgent intubation during 6 months were eligible. Patients were randomized in a single-blinded manner to either intravenous diazepam or midazolam. Diazepam was ...

BACKGROUND/AIMS Endoscopic retrograde cholangiopancreatography (ERCP) is an uncomfortable procedure that requires adequate sedation for its successful conduction. We investigated the efficacy and safety of the combined use of intravenous midazolam and propofol for sedation during ERCP. METHODS A retrospective review of patient records from a single tertiary care hospital was performed. Ninety...

BACKGROUND/AIMS To assess patient preferences for different anaesthesia management strategies during cataract surgery. METHODS Cross sectional clinic based study of patient preferences for anaesthesia management strategies. Patients rated their preferences using a linear rating scale from 0 to 100. RESULTS Subjects tended to prefer block to topical anaesthesia and oral to intravenous sedati...

Few cases of bradycardic complications occurring under intravenous sedation have been reported. Here, we report a case of vasovagal syncope with asystole (7.2 seconds) associated with propofol sedation.

Introduction Use of inhalation anesthetic sevoflurane has some potential advantages over intravenous sedation in adult survivors of cardiac arrest. Wake-up times are shorter compared to intravenous sedation, neurologic assessment could potentially be performed sooner and there are reports of possible protection against ischaemicreperfusion injury. There are no prospective studies or guidelines ...

BACKGROUND Propofol is a popular agent for providing intraoperative sedation in pediatric population during lumbar puncture and spinal anesthesia. Adjuvant-like clonidine is used increasingly in pediatric anesthesia to provide postoperative analgesia with a local anesthetic agent. The aim of this study was to assess the effects of intrathecal and intravenous clonidine on postoperative analgesia...

BACKGROUND Benzodiazepines, such as lorazepam and midazolam, are frequently administered to surgical intensive care unit (ICU) patients for postoperative sedation. To date, the pharmacology of lorazepam in critically ill patients has not been described. The aim of the current study was to characterize and compare the pharmacokinetics and pharmacodynamics of lorazepam and midazolam administered ...

We compared the efficacy of intranasal midazolam, ketamine and their mixture as premedication in children with tetralogy of Fallot (TOF) using bispectral index (BIS), sedation score and separation score at the time of separation from parent. Sedation score at the time of intravenous cannulation was also measured. Children with TOF physiology were randomly divided into three equal groups of 20 e...