We report the occurrence of supraventricular tachycardia during intravenous immunoglobulin (IVIG) infusion. Supraventricular tachycardia was observed in two newborn patients during IVIG infusion. Both of the babies responded to adenosine treatment. Cardiorespiratory monitoring during IVIG infusion can be recommended because of the possibility of this potentially lifethreatening adverse effect.

We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels. The case illustrates that IVIG may not prevent VZV infection.

BACKGROUND Cerebellar syndrome and small fiber neuropathy may complicate celiac disease (CD) and may be resistant to a strict gluten-free diet. METHODS Case series. RESULTS We report three patients with biopsy-proven CD who developed cerebellar ataxia and neuropathic pain despite strict adherence to a gluten-free diet. A small fiber neuropathy was suggested by skin biopsy findings in two pa...

Background Intravenous Immunoglobulin (IVIG) is widely used in paediatric inflammatory disease. The Department of Health, UK recently produced guidelines for IVIG use and a demand management plan in response to global IVIG shortages, recommending use in "selected" patients with juvenile dermatomyositis (JDMS), as a "last resort" in systemic juvenile idiopathic arthritis (sJIA), and use not supp...

Immunoglobulins (antibodies) are plasma proteins produced by B cells, which are essential in the defence against bacterial and viral infections. Dysregulation of the immune system can lead to the formation of autoantibodies and subsequent autoimmune disease. Therapy with immunoglobulin was first studied in the late 19th century, when Von Behring and Kitasato showed that serum taken from rabbits...

BACKGROUND [corrected] Intravenous immunoglobulin administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis, although its mode of action and active components have not yet been fully identified. OBJECTIVES To isolate from IVIg a disease-specific fraction involved in the therapeutic activity in myasthenia and to identify its pro...

Aims: To assess potential changes of pharmacological activities a novel normal immunoglobulin for intravenous administration from pooled plasma (IVIG). Methods: We assessed the impact SARS-CoV-2 pandemic on level and activity pathogen-specific antibodies in IVIG batches produced before during pandemic. Antibody levels were determined by immunoassays. The functional was vitro neutralization. Res...

There is a large number of immunodeficient patients requiring lifelong IgG replacement. This review is focused on currently available Intravenous Immunoglobulin (IVIG) preparations, manufacturing procedures, dose arrangements, mechanisms of actions, benefits of antibody replacement treatment and careful administration of IVIG considering, numerous side effects. Subcutaneous IgG (SCIG) treatment...

Intravenous immunoglobulin (IVIg) has been shown to be effective for a variety of autoimmune diseases. Despite its widespread use and therapeutic success, the precise mechanisms for the anti-inflammatory therapeutic effects of IVIg are not well understood. In particular, few reports have examined the mechanism of IVIg on regulatory T cells (Treg: CD4(+)CD25(+)FoxP3(+) T cells). In the present s...

Recurrent pregnancy loss associated with immunologic abnormalities has been termed immunologic abortion. Immunologic abortion occurs primarily in women over the age of 30 years and may affect either natural or in-vitro fertilization (IVF)-induced pregnancy. In this article, we review the humoral and cellular immunologic abnormalities that have been associated with this form of recurrent abortio...